Here, Bert Vogelstein & team report that increasing binding affinity to a p53 R175H neoantigen improves anti-cancer activity for T cell-engaging bispecific antibodies and conversely decreases function for CAR T cells.
1Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
2Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
3Lustgarten Pancreatic Cancer Research Laboratory and.
4Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.