Here, Peter Arvan & team generate a mouse model lacking thyroglobulin, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress:

The figure shows limited ER diameter in thyroid tissue from Tg-KO untreated mice.

Address correspondence to: Peter Arvan, Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Brehm Tower rm 5,112, 1000 Wall Street, Ann Arbor, Michigan 48,105, USA. Phone: 734.936.5505; Email: [email protected].