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A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells

Harnessing antibodies found in patients with lupus, researchers test a new cancer therapy that turns autoimmune responses against tumor cells in mice, suggesting similar approaches could be integrated into immunotherapy regimens.

Learn more in Science Signaling.


Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.

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