The bone marrow is home to the production of red and white blood cells. Many blood disorders also arise here, making it a relevant site to study. However, its complexity made it difficult for researchers to model.

Now, researchers at the Universität Basel developed a 3D system to reproduce the architecture and major function of this niche.

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Organoids cultured on a bone scaffold created a vascularized model of the human endosteal niche, paving the way for more reliable studies of the bone marrow.