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How T cells transform to defend our organs

We owe a lot to tissue resident memory T cells (TRM). These specialized immune cells are among the body’s first responders to disease.

Rather than coursing through the bloodstream—as many T cells do—our TRM cells specialize in defending specific organs. They battle viruses, , , melanomas, and many other health threats.

Pandurangan Vijayanand, M.D., Ph.D., William K. Bowes Distinguished Professor at La Jolla Institute for Immunology (LJI), has even shown that a greater density of TRM cells is linked to better survival outcomes in lung cancer patients.

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