Epstein-Barr virus (EBV) infected and reprogrammed autoreactive B cells in patients with systemic lupus erythematosus (SLE) to become activated antigen-presenting cells. EBV-infected B cells in patients with SLE showed increased antigen-presenting capabilities, unlike those in healthy control individuals, and may serve as drivers of systemic autoimmune responses.

Epstein-Barr virus reprograms autoreactive B cells, possibly contributing to systemic lupus erythematosus, with infected B cells in patients showing high antigen-presenting capabilities.