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Prefrontal cortex astrocytes modulate distinct neuronal populations to control anxiety-like behavior

Whether and how prefrontal astrocyte Ca2+ signaling modulates different neuronal populations in aiding or inhibiting anxiety-like behavior remains not fully understood. Here authors show that prefrontal astrocytes encode anxiogenic cues and modulate excitatory and inhibitory neurons differently. Silencing prefrontal astrocytes heightens anxiety-like behavior and induces proteomic changes in astrocytes and neurons.

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