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Quantifying the evolutionary paths to endomembranes

Schavemaker and Lynch derived functions that relate the cell biology of endomembranes to cellular fitness. Applied to the pinocytosis of small-molecule nutrients and the insertion of membrane proteins by a proto-endoplasmic reticulum, the proto-endoplasmic reticulum is revealed to be the more likely path to complex endomembranes in the origin of eukaryotes.

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