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Differential dendritic integration of long-range inputs in association cortex via subcellular changes in synaptic AMPA-to-NMDA receptor ratio

Lafourcade et al. reveal that apical oblique dendrites of retrosplenial cortical L5 neurons exhibit unexpectedly linear integration compared with basal and tuft branches via increased synaptic AMPA: NMDA. Long-range inputs are targeted to these distinct dendritic domains, supporting the idea that single neurons perform a diverse range of subcellular processing.

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