A four-year-old boy with a life-threatening immune disease is now living a normal life thanks to a pioneering gene therapy trial.

Eisa Hussain, who suffers from a severe form of leukocyte adhesion deficiency 1 (LAD-1), can now play football and attend school – milestones his family once thought impossible.

LAD-1 cripples the immune system, leaving children vulnerable to infections. Without treatment, the most severe cases are often fatal before the age of two.