An international team of researchers has discovered that rifaximin, a commonly prescribed antibiotic for liver disease patients, is contributing to the global rise of a highly resistant strain of vancomycin-resistant Enterococcus faecium (VRE). This superbug, which frequently causes severe infections in hospitalized patients, is becoming increasingly difficult to treat.

The study, published in Nature, reveals that rifaximin use is accelerating resistance to daptomycin—one of the last remaining effective antibiotics against VRE infections.

Led by scientists from the University of Melbourne’s Peter Doherty Institute for Infection and Immunity (Doherty Institute) and Austin Health, the research underscores the urgent need for a more comprehensive understanding of the unintended consequences of antibiotic use. It highlights the critical importance of responsible antibiotic prescribing to mitigate the spread of antimicrobial resistance.