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Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis

A new Science Immunology study shows that disruptions to immunosuppressive intraepithelial lymphocytes and intestinal immunity occurs prior to the onset of chronic ileal inflammation in mouse models of Crohn’s Disease.


Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

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