The glymphatic system becomes more active during sleep, especially during deep sleep, allowing for more effective waste clearance, said psychiatrist Dr. Jingduan Yang, founder of the Yang Institute of Integrative Medicine in Pennsylvania.
In a mouse study published in Science, researchers used tracers to monitor changes in cerebrospinal fluid flow. They found that during sleep, the interstitial, or intervening, space expanded by more than 60 percent, and the tracer influx increased. The brain’s clearance rate of beta-amyloid doubled during sleep (or under anesthesia) compared to the awake state.
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