One of the ways cells in different kinds of tissue communicate is by exchanging RNA molecules. In experiments with roundworms of the species Caenorhabditis elegans, researchers at the State University of Campinas (UNICAMP) in Brazil found that when this communication pathway is dysregulated, the organism’s lifespan is shortened.
An article on the study is published in the journal Gene. The findings contribute to a better understanding of the aging process and associated diseases.
“Previous research showed that some types of RNA can be transferred from one cell to another, mediating intertissue communication, of the kind that occurs with proteins and metabolites, for example. This is considered a mechanism for signaling between organs or neighboring cells. It’s part [of the physiopathology] of several diseases and of the organism’s normal functioning,” said Marcelo Mori, corresponding author of the article and a professor at the Institute of Biology (IB-UNICAMP).
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