Researchers have pioneered a 3D-SPI method that allows high-resolution imaging of microscopic objects, presenting a transformative approach for future biomedical research and optical sensing.
A research team led by Prof. Lei Gong from the University of Science and Technology (USTC) of the Chinese Academy of Sciences (CAS) and collaborators developed a three-dimensional single-pixel imaging (3D-SPI) approach based on 3D light-field illumination(3D-LFI), which enables volumetric imaging of microscopic objects with a near-diffraction-limit 3D optical resolution. They further demonstrated its capability of 3D visualization of label-free optical absorption contrast by imaging single algal cells in vivo.
The study titled “Optical Single-Pixel Volumetric Imaging by Three-dimensional Light-Field Illumination” was published recently in the journal Proceedings of the National Academy of Sciences (PNAS).
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