Ovarian cancer is the fourth-leading cause of cancer mortality among women and is characterized by late detection, extensive metastasis and poor prognosis.
One reason that treating this disease has been so challenging is that tumors often become resistant to chemotherapies, and generally respond poorly to immunotherapies.
While much of the research on overcoming resistance and efforts to develop new therapies have focused on the cancer cells, it has often ignored the many other cell types within the tumor. Indeed, cancer cells have the ability to reprogram the cells around them to nurture the tumor and help evade the patient’s immune system.
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