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Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids Communications

Year 2021


Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.