Combining an optical tweezer technology called C-trap that manipulates a single molecule of DNA and a novel approach, researchers were able to receive a detailed view into how cells find and repair damaged DNA.
Their findings are described in an article titled, “Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE),” published in Nucleic Acids Research.
In the new study, the researchers used the C-trap to investigate how different DNA repair proteins identify and bind to their respective forms of damage.
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