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Dec 21, 2022

Study unveils neural pathway promoting regeneration after traumatic injuries

Posted by in category: neuroscience

๐’๐ญ๐ฎ๐๐ฒ ๐ฎ๐ง๐ฏ๐ž๐ข๐ฅ๐ฌ ๐ง๐ž๐ฎ๐ซ๐š๐ฅ ๐ฉ๐š๐ญ๐ก๐ฐ๐š๐ฒ ๐ฉ๐ซ๐จ๐ฆ๐จ๐ญ๐ข๐ง๐  ๐ซ๐ž๐ ๐ž๐ง๐ž๐ซ๐š๐ญ๐ข๐จ๐ง ๐š๐Ÿ๐ญ๐ž๐ซ ๐ญ๐ซ๐š๐ฎ๐ฆ๐š๐ญ๐ข๐œ ๐ข๐ง๐ฃ๐ฎ๐ซ๐ข๐ž๐ฌ

๐™Ž๐™ฉ๐™ช๐™™๐™ž๐™š๐™จ ๐™š๐™ญ๐™ฅ๐™ก๐™ค๐™ง๐™ž๐™ฃ๐™œ ๐™ฉ๐™๐™š ๐™ฃ๐™š๐™ช๐™ง๐™–๐™ก ๐™ฅ๐™ง๐™ค๐™˜๐™š๐™จ๐™จ๐™š๐™จ ๐™ž๐™ฃ๐™ซ๐™ค๐™ก๐™ซ๐™š๐™™ ๐™ž๐™ฃ ๐™˜๐™š๐™ก๐™ก ๐™ง๐™š๐™œ๐™š๐™ฃ๐™š๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™–๐™ง๐™š ๐™ค๐™› ๐™˜๐™ง๐™ช๐™˜๐™ž๐™–๐™ก ๐™ž๐™ข๐™ฅ๐™ค๐™ง๐™ฉ๐™–๐™ฃ๐™˜๐™š, ๐™–๐™จ ๐™ฉ๐™๐™š๐™ฎ ๐™˜๐™ค๐™ช๐™ก๐™™ ๐™ฅ๐™–๐™ซ๐™š ๐™ฉ๐™๐™š ๐™ฌ๐™–๐™ฎ ๐™ฉ๐™ค๐™ฌ๐™–๐™ง๐™™๐™จ ๐™ฉ๐™๐™š ๐™™๐™š๐™ซ๐™š๐™ก๐™ค๐™ฅ๐™ข๐™š๐™ฃ๐™ฉ ๐™ค๐™› ๐™ข๐™ค๐™ง๐™š ๐™š๐™›๐™›๐™š๐™˜๐™ฉ๐™ž๐™ซ๐™š ๐™ฉ๐™ง๐™š๐™–๐™ฉ๐™ข๐™š๐™ฃ๐™ฉ๐™จ ๐™›๐™ค๐™ง ๐™ข๐™–๐™ฃ๐™ฎ ๐™ฅ๐™–๐™ฉ๐™๐™ค๐™ก๐™ค๐™œ๐™ž๐™š๐™จ ๐™–๐™จ๐™จ๐™ค๐™˜๐™ž๐™–๐™ฉ๐™š๐™™ ๐™ฌ๐™ž๐™ฉ๐™ ๐™ฉ๐™๐™š ๐™ข๐™ช๐™ฉ๐™–๐™ฉ๐™ž๐™ค๐™ฃ๐™จ ๐™ค๐™ง ๐™™๐™š๐™ฉ๐™š๐™ง๐™ž๐™ค๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™ค๐™› ๐™˜๐™š๐™ก๐™ก๐™จ. ๐™ˆ๐™ž๐™˜๐™ง๐™ค๐™œ๐™ก๐™ž๐™–, ๐™ฉ๐™๐™š ๐™—๐™ง๐™–๐™ž๐™ฃโ€™๐™จ ๐™ง๐™š๐™จ๐™ž๐™™๐™š๐™ฃ๐™ฉ ๐™ž๐™ข๐™ข๐™ช๐™ฃ๐™š ๐™˜๐™š๐™ก๐™ก๐™จ, ๐™—๐™š๐™˜๐™ค๐™ข๐™š ๐™–๐™˜๐™ฉ๐™ž๐™ซ๐™š ๐™ž๐™ฃ ๐™ง๐™š๐™จ๐™ฅ๐™ค๐™ฃ๐™จ๐™š ๐™ฉ๐™ค ๐™ฅ๐™–๐™ฉ๐™๐™ค๐™ก๐™ค๐™œ๐™ž๐™š๐™จ, ๐™จ๐™ค๐™ข๐™š๐™ฉ๐™ž๐™ข๐™š๐™จ ๐™ก๐™š๐™–๐™™๐™ž๐™ฃ๐™œ ๐™ฉ๐™ค ๐™˜๐™๐™ง๐™ค๐™ฃ๐™ž๐™˜ ๐™ž๐™ฃ๐™›๐™ก๐™–๐™ข๐™ข๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™–๐™ฃ๐™™ ๐™ฉ๐™๐™š ๐™จ๐™˜๐™–๐™ง๐™ง๐™ž๐™ฃ๐™œ ๐™ค๐™› ๐™ฉ๐™ž๐™จ๐™จ๐™ช๐™š.


Studies exploring the neural processes involved in cell regeneration are of crucial importance, as they could pave the way towards the development of more effective treatments for many pathologies associated with the mutations or deterioration of cells. Microglia, the brainโ€™s resident immune cells, become active in response to pathologies, sometimes leading to chronic inflammation and the scarring of tissue.

Cell regeneration mechanisms thus regulate the reactivity of different glial cells, including microglia, preventing further damage and promoting recovery. While many past studies have explored the processes involved in inflammation, many questions about how the brain can successfully recover after injuries or pathologies remain unanswered.

Researchers at LMU Munich, Helmholtz Zentrum Munich, Johannes Gutenberg-Universitรคt (JGU), and other institutes in Germany have recently carried out a study on zebrafish aimed at better understanding the processes underpinning brain regeneration in both animals and humans. Their findings, published in Nature Neuroscience, unveiled a microglial state characterized by the accumulation of lipid droplets and TDP-43+, a RNA-binding protein, which delayed or prevented post-injury brain regeneration.

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