๐๐๐ฐ ๐๐ญ๐ฅ๐๐ฌ:
The Neuro-Network.
๐๐ง๐ณ๐ฒ๐ฆ๐ ๐๐ฅ๐จ๐๐ค๐๐ซ ๐๐จ๐ฎ๐ฅ๐ ๐จ๐ฉ๐๐ง ๐ง๐๐ฐ ๐ญ๐ซ๐๐๐ญ๐ฆ๐๐ง๐ญ๐ฌ ๐๐จ๐ซ ๐ง๐๐ฎ๐ซ๐จ๐๐๐ ๐๐ง๐๐ซ๐๐ญ๐ข๐ฏ๐ ๐๐ข๐ฌ๐๐๐ฌ๐๐ฌ
๐๐๐จ๐๐๐ง๐๐๐๐ง๐จ ๐๐๐ซ๐ ๐ช๐ฃ๐๐ค๐ซ๐๐ง๐๐ ๐๐ค๐ฌ ๐ ๐๐๐ง๐ฉ๐๐๐ฃ ๐ข๐ค๐ก๐๐๐ช๐ก๐๐ง ๐ฅ๐๐ฉ๐๐ฌ๐๐ฎ ๐ฉ๐ง๐๐๐๐๐ง๐จ ๐ฉ๐๐ ๐๐ง๐๐๐ ๐๐ค๐ฌ๐ฃ ๐ค๐ ๐ฃ๐๐งโฆ See more.
Researchers have uncovered how a certain molecular pathway triggers the breakdown of nerve fibers in neurodegenerative diseases โ and more importantly, how to potentially switch it off. The find could lead to a new class of drugs that slows the progression of these debilitating disorders.
The focus of the study was an enzyme called SARM1, which is expressed in neurons and plays a role as an immune regulator. However, it also functions as a sensor of metabolic stress, and at a certain point it sparks a cascade of processes that eventually begins to break down axons, leading to some of the issues associated with Parkinsonโs disease, ALS, neuropathy, and other neurodegenerative diseases.
But exactly what is going on during that process has remained murky, so the researchers on the new study investigated closer using nuclear magnetic resonance (NMR) spectroscopy, cryo-electron microscopy and X-ray crystallography.