A previously unidentified cell population in the pericardial fluid found within the sac around the heart has been identified in a collaborative study at the University of Calgary which may lead to new treatments for those with injured hearts, as published in the journal Immunity.
Discovered in the pericardial fluid of a mouse with heart injury, a Gata6+ pericardial cavity macrophage cell was found to help heal injured hearts in mice; the same cells were also found within human pericardium of those with injured hearts, confirming the repair cells offer promise of a new therapy for patients with heart disease.
“The fuel that powered this study is the funding from the Heart and Stroke Foundation of Canada, the collaboration between two major research institutes at CSM (Snyder and Libin) and the important contribution of philanthropy from the Libin and Snyder families to obtain imaging equipment available to very few programs globally,” says Dr. Paul Kubes.
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