A recent study led by a team of researchers at The Johns Hopkins University School of Medicine examining aging mice has provided what is believed to be the first evidence that amyloid beta protein—small, sticky protein fragment found in people with Alzheimer’s disease (AD)—particles build up in the bone marrow of the animals, although not in the exact same form as the large, dense plaques found in the brains of people with Alzheimer’s disease.
“Although amyloid buildup has been found in organs outside the brain—such as the heart, kidneys, and nerves—it remains unclear whether similar deposits form in bone or bone marrow with aging or in Alzheimer’s disease,” says contributing study author Mei Wan, Ph.D., professor of the department of Orthopedic Surgery.
“While brain amyloid has been extensively studied for its role in memory loss and neurodegeneration, far less is known about amyloid elsewhere in the body. In fact, almost nothing is known about whether amyloid forms in the skeleton or how it might contribute to age-related bone loss.”
Young chimpanzees learn their communication style from their mother and maternal relatives, but show little similarity to the communication behavior of their father and paternal relatives, according to a study published in the open-access journal PLOS Biology by Joseph Mine at the University of Zurich, Switzerland, and colleagues.
The hosts delve into “The Future of Science” (Будущее Науки) by Viktor Filaletov (Виктор Филалетов), offering a profound exploration of science’s fundamental nature, evolving methodology, and crucial future prospects. The sources consistently portray science as a systematic process of knowledge acquisition, driven by the meticulous study of regularities and an unwavering commitment to understanding reality. At its core, scientific activity involves rigorous observation, precise experimentation, and the development of robust theories through the generalization of observations and facts. This entire scientific work is depicted as a deeply intellectual activity, fueled by intellectual curiosity and the unyielding pursuit of objective truth.
A significant focus is placed on scientific methodology, highlighting the importance of systematic research, the interplay of logic and intuition, and precise data analysis in tackling diverse scientific problems and achieving groundbreaking scientific discoveries. Scientific progress is depicted as a continuous, dynamic process, requiring constant critical thinking, scientific skepticism, and an openness to challenge established theoretical frameworks for ongoing intellectual development. The text distinguishes between fundamental research and applied research, acknowledging the vital role of both in advancing knowledge and understanding the world.
The sources candidly address the inherent challenges in scientific research, including navigating uncertainty in science and confronting the inherent limits of human understanding and perception. They underscore the vital human element, where scientific thought and scientific creativity are integral to the investigative process. Furthermore, crucial ethical considerations and profound scientific responsibility are discussed, particularly regarding the immense societal impact of science and its implications for future generations. The relentless pursuit of scientific truth often necessitates confronting the unknown and achieving scientific validation through empirical evidence. The text also touches upon the philosophical aspects of science and the importance of scientific integrity in all endeavors.
Looking towards the future of science, the discourse emphasizes relentless innovation and accelerated technological advancement. A compelling and recurring theme is the necessity of interdisciplinary research and expanded global scientific collaboration to effectively address and solve complex global challenges. The ongoing evolution of scientific thought and collective intellectual development are posited as essential drivers for uncovering new scientific breakthroughs and pushing the very frontiers of knowledge. Ultimately, scientific inquiry is presented as an unending pursuit of understanding, continually redefining our comprehension of the world and ensuring the future of scientific endeavor remains vibrant and impactful. #science #philosophy #FutureOfScience #ScientificResearch #ScienceProgress #KnowledgeDiscovery #HumanityForward #deepdive #skeptic #podcast #synopsis #books #bookreview #science #aiart #ai #artificialintelligence #booktube #aigenerated #videoessay
Since its release in November of 2022, the use of ChatGPT and other large language models (LLMs) has proliferated throughout many disciplines, providing writing assistance for everything from speeches to contracts. So, it may not be surprising that some scientists might utilize ChatGPT to quicken the pace at which they publish their research.
Adjuvant immunotherapy plus chemotherapy has yet to square off against neoadjuvant immunotherapy in a head-to-head trial. Even if that trial doesn’t happen, post hoc analyses of ATOMIC and the neoadjuvant NICHE-2 studies may clarify whether a one-size-fits-all approach is appropriate and help determine which patients benefit more from one approach over the other, according to Christopher Lieu, MD, an investigator in the ATOMIC study.
The ATOMIC study showed that adding adjuvant immunotherapy to standard-of-care chemotherapy following resection reduced the risk for disease recurrence or death by 50% compared with chemotherapy alone in the 355 patients with stage III colon cancer with mismatch repair deficiency (dMMR), who received adjuvant atezolizumab along with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy, providing those in the pro-adjuvant camp with important data. In addition, 3-year disease-free survival (DFS) was 86.4% with the combination compared with 76.6% with chemotherapy alone. The results of this trial were presented at the American Society of Clinical Oncology (ASCO) 2025.
Experts debate which patients with stage III dMMR colon cancer will benefit from the two treatment approaches.
Emerging technologies, such as autonomous vehicles, drones, and humanoid robotics, are rapidly transforming industries and revolutionizing transportation, logistics, and other sectors, driven by decreasing costs, economic incentives, and significant investments.
Questions to inspire discussion.
Emerging Technologies 🚁 Q: How are drones revolutionizing delivery services? A: Drones are delivering millions of goods with insane energy efficiency, cost-effectiveness, and convenience, exemplified by Google’s Wing program partnering with Walmart and DoorDash, and Zipline saving half a million lives delivering medicine worldwide. 🤖 Q: What roles can humanoid robots fill in the workforce?
In this Review the authors explain how different routes of exposure to food antigens can contribute to the development of food allergies. They discuss how allergic sensitization occurs against food antigens and focus on how IgE and mast cells ultimately drive the allergic pathology.
Serendipitously and for the first time, an international research team led by scientists at the U.S. Department of Energy’s SLAC National Accelerator Laboratory formed solid binary gold hydride, a compound made exclusively of gold and hydrogen atoms.
The researchers were studying how long it takes hydrocarbons, compounds made of carbon and hydrogen, to form diamonds under extremely high pressure and heat.
In their experiments at the European XFEL (X-ray Free-Electron Laser) in Germany, the team studied the effect of those extreme conditions in hydrocarbon samples with an embedded gold foil, which was meant to absorb the X-rays and heat the weakly absorbing hydrocarbons. To their surprise, they not only saw the formation of diamonds, but also discovered the formation of gold hydride.
In the subatomic universe of quantum physics, you can achieve things considered impossible in our flesh-and-blood physical world. Things like superposition, entanglement, and even teleportation all seem possible when things go quantum. Now, scientists from the Austrian Academy of Sciences (ÖAW) and University of Vienna are adding a kind of time travel to the list.
In a series of papers published on preprint servers and in various online journals (including Optica, arXiv, and Quantum), researchers including ÖAW’s Miguel Navascués and University of Vienna’s Philip Walther explain the possibility of speeding up, slowing down, and even reversing the flow of time within a quantum system.
New research has uncovered a novel mechanism that may help explain why some people with cancer respond remarkably well to immunotherapy while others don’t.
Researchers from the Garvan Institute of Medical Research and UNSW Sydney have uncovered that less active versions of a gene called NOD2, in combination with radiotherapy or immunotherapy, may help supercharge the immune system’s ability to attack cancer.
The findings, published in the journal Proceedings of the National Academy of Sciences, could pave the way for more personalized and effective immunotherapy treatments against a range of cancers.
