Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 9900

ORACLE, Ariz. — They lived for two years and 20 minutes under the glass of a miniature Earth, complete with an ocean, rain forest, desert, grasslands and mangroves. Their air and water were recycled, and they grew the sweet potatoes, rice and other food they needed to survive.

About 1,500 people were invited and some 200 journalists were on hand as the eight original inhabitants of Biosphere 2 left their glass terrarium a quarter-century ago last month in two groups that no longer talked to each other amid the stress of sharing a small space and disputes over how the project should be run. Detractors called the $150 million experiment a failure because additional oxygen was pumped into what was supposed to be a self-sustaining system.

A power struggle in subsequent months led the financial backer, Texas billionaire Edward Bass, to hire investment banker Stephen Bannon, who was later President Trump’s chief strategist, to bring the project back from financial disarray.

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China wants to integrate four areas for stronger AI. China will use abundant data, hungry entrepreneurs, many AI scientists, and AI-friendly policy.

29 U.S. states have enacted their own laws regulating autonomous vehicles. And governors in 10 states have issued executive orders curbing testing and use.

In 2018, China adopted national self-driving car guidelines that allow any city to perform tests on self-driving cars. China has started engineering multi-tiered roads and entire cities tailored to incorporate driverless vehicles.

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Vera, as the technology’s been dubbed, was unveiled in September, and consists of a sort of flat-Tesla-like electric car with a standard trailer hookup. The vehicles are connected to a cloud service, which also connects them to each other and to a control center. The control center monitors the trucks’ positioning (they’re designed to locate their position to within centimeters), battery charge, load content, service requirements, and other variables. The driveline and battery pack used in the cars are the same as those Volvo uses in its existing electric trucks.

You won’t see these cruising down an interstate highway, though, or even down a local highway. Vera trucks are designed to be used on short, repetitive routes contained within limited areas—think shipping ports, industrial parks, or logistics hubs. They’re limited to slower speeds than normal cars or trucks, and will be able to operate 24/7. “We will see much higher delivery precision, as well as improved flexibility and productivity,” said Mikael Karlsson, VP of Autonomous Solutions at Volvo Trucks. “Today’s operations are often designed according to standard daytime work hours, but a solution like Vera opens up the possibility of continuous round-the-clock operation and a more optimal flow. This in turn can minimize stock piles and increase overall productivity.”

The trucks are sort of like bigger versions of Amazon’s Kiva robots, which scoot around the aisles of warehouses and fulfillment centers moving pallets between shelves and fetching goods to be shipped.

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A peroxide scavenger nanoparticle reduces systemic inflammation in mouse models.

With 19 million cases per year worldwide, sepsis is one of the most life-threatening conditions in the intensive care unit. However, to date, there is no specific and effective treatment. Oxidative stress has been shown to play a major role in sepsis pathogenesis by altering the systemic immune response to infections, which, in turn, may lead to multiorgan dysfunction and cognitive impairment. Here, Rajendrakumar et al. developed a nanoparticle-based peroxide scavenger treatment for reducing oxidative stress during sepsis.

To produce the nanoassembly, the authors first developed a water-soluble nanoparticle core containing an active peroxide scavenger and a protein that stabilizes the scavenger and improves its biocompatibility. The nanoparticle core was then coated with a polymer material conjugated with mannose to help the final nanoassembly target inflammatory immune cells through the mannose receptor on the immune cell surfaces. The authors first confirmed in cell cultures that the nanoassembly can selectively reduce hydrogen peroxide–mediated free radical production with minimal toxicity. In cultures, immune cells demonstrated enhanced intracellular uptake of the particles and reduced production of inflammatory markers during activation. To demonstrate the therapeutic efficacy in vivo, the authors carried out three sets of animal studies. In the first set, the nanoassembly was shown to reduce locally induced tissue inflammation and prevent inflammatory immune cell infiltration.

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