This website uses a security service to protect against malicious bots. This page is displayed while the website verifies you are not a bot.
Get the latest international news and world events from around the world.
Elevated phagocytic capacity directs innate spinal cord repair
Klatt Shaw et al. report that transient activation of zebrafish macrophages directs spontaneous regeneration after spinal cord injury. By comparing regenerative and non-regenerative vertebrates, they identify Tcim as a central regulator of lipid metabolism and phagocytosis following injury. Tcim expression enhances lipid and debris clearance in zebrafish and mouse macrophages.
Rare footage of humpback whale birth captured on drone video: “A remarkable moment”
Forrest was joined by members of ORRCA’s team, who continued to monitor the mother and calf over several hours, “collecting observations during the critical first hours of the calf’s life,” the organization said on social media.
The footage is believed to be only the fourth complete humpback whale birth ever recorded on film anywhere in the world and the first-ever captured by drone.
“Every observation like this has the potential to expand our understanding of humpback whale reproduction, maternal behaviour and the earliest stages of a calf’s life,” ORRCA said.
Can We Defeat Human Aging?
For all of human history, death has been the one certainty.
That certainty is now being challenged.
The biggest names in longevity research believe aging can be slowed, reversed, and one day eliminated. AI researchers think biology is simply another puzzle waiting to be solved. Together, they may be building the technology that changes civilization forever.
But extending life isn’t the real story.
The real story is what happens when humanity no longer has an expiration date.
This is the science, the debate, and the future of defeating aging.
MicroRNA-based gene therapy to treat ALS
A single IV injection of a microRNA-based biologic suppressed production of the mutant SOD1 protein that causes amyotrophic lateral sclerosis (ALS); delayed disease onset by 60 days; and extended lifespan by 100 days, more than triple the average survival time, in mice models of the disease.
The gene therapy, delivered via adeno-associated virus (AAV) vector, preserved motor neurons and maintained neuromuscular connections in treated animals, which translated into improved muscle and respiratory function, motor performance, and lifespan in pre-clinical studies. These findings, published in Nature Communications, have the potential for clinical application in patients with SOD1-caused ALS, as well as other neurodegenerative diseases caused by toxic, gain-of-function gene mutations.
“These therapeutic benefits, from a single IV injection, are unprecedented among gene therapy approaches in this mouse model,” said the senior author. “No other studies have been able to achieve this kind of survival extension. This makes us very optimistic that our approach could have a meaningful impact for patients suffering from this horrible disease and warrants further clinical evaluation.”
Overcoming Cancer Resistance: Strategies and Modalities for Effective Treatment
Resistance to cancer drugs is a complex phenomenon that poses a significant challenge in the treatment of various malignancies. This review comprehensively explores cancer resistance mechanisms and discusses emerging strategies and modalities to overcome this obstacle. Many factors contribute to cancer resistance, including genetic mutations, activation of alternative signaling pathways, and alterations in the tumor microenvironment. Innovative approaches, such as targeted protein degradation, immunotherapy combinations, precision medicine, and novel drug delivery systems, hold promise for improving treatment outcomes. Understanding the intricacies of cancer resistance and leveraging innovative modalities are essential for advancing cancer therapy.