Lifeboat Foundation

The fusion of a sperm cell with an egg cell is the very first step in the process that leads to new individuals in sexually reproducing species. Fundamental as this process may be, scientists are only now beginning to understand the complexities of how it works.

In a paper published in PLOS Biology, researchers have described the detailed structure of proteins that enable sperm-egg fusion in two different species: a flowering plant and a protozoan. The researchers hope that revealing the process in these species and their relatives might bring scientists a step closer to understanding it across sexual species, including humans and other vertebrates.

“It’s surprising to me that we still don’t know how a human sperm fuses with a human egg,” said Mark Johnson, an associate professor of biology at Brown University and a study co-author. “One of the things we hope this paper will do is establish a structural signature for the proteins that make gamete fusion work in these species so that we might be able to look for it in species where those protein mechanisms are still unknown.”

For the last 20 million years, the species of yeast used to brew beer has had 16 chromosomes. Now scientists have created a new species with just one.

This is not sustainable!

Every summer the U.S. Central Plains go dry, leading farmers to tap into groundwater to irrigate sorghum, soy, cotton, wheat and corn and maintain large herds of cattle and hogs. As the heat rises, anxious irrigators gather to discuss whether and how they should adopt more stringent conservation measures.

They know that if they do not conserve, the Ogallala Aquifer, the source of their prosperity, will go dry. The Ogallala, also known as the High Plains Aquifer, is one of the largest underground freshwater sources in the world. It underlies an estimated 174,000 square miles of the Central Plains and holds as much water as Lake Huron. It irrigates portions of eight states, from Wyoming, South Dakota and Nebraska in the north to Colorado, Kansas, Oklahoma, New Mexico and Texas in the south.

Continue reading “Farmers are drawing groundwater from the giant Ogallala Aquifer faster than nature replaces it” »

Loggers need to control their appetite for slow-growing trees to spare the Amazon rainforest from deforestation.

A new study by Ph.D. student J. Aaron Hogan points to changes in tree composition in a long-term study site in French Guiana to sound the alarm.

“We’re approaching a threshold where we’re forced to make some difficult decisions,” Hogan said. “Do we feed into demand for these tropical hardwoods? Or do we stick to our guns and say you can’t log any more until this stand is regenerated.”

Australia’s population clock is, according to the Australian Bureau of Statistics, steadily ticking away at an overall total population increase of one person every 1 minute and 23 seconds. It’s set to tick over to 25 million around 11pm tonight.

Many are debating what the ideal population is for a country like Australia. But because most of this population growth is concentrated in our big cities, perhaps we should be thinking less about that and more about the ideal size of a city. Historically, there have been many theories on what this would be.

Today, we wanted to draw your attention to a review of aging and the role that the gut microbiome plays in it.

There is an increasing amount of evidence for the contribution of microbial burden in the chronic, age-related background of inflammation known as “inflammaging”. There are a number of proposed sources of inflammaging, including senescent cells, immunosenescence, cell debris, and microbial burden.

We have delved into the topic of the gut microbiome in the past and its possible role as the origin point of inflammaging in a previous article, but we wanted to highlight this publication for people interested in reading further about this rapidly evolving area of aging research [1].

We could make people less stinky, more resistant to radiation, even less dependent on food and oxygen. But would the new creature be human?

For centuries humans have sought the ‘elixir of life’ – a mythical potion that supposedly would grant the drinker eternal life.

Now Exeter scientists believe they may have found the secret to a longer, healthier life.

New compounds developed and tested at the University of Exeter have brought the dream a step closer and paved the way for “anti-degeneration” drugs that could not only extend life, but also extend health and may help treat age-related diseases like cancer, dementia and diabetes.

Continue reading “Exeter University boffins have discovered ‘elixir of life’” »

The compounds — AP39, AP123 and RT01 — have been designed to selectively deliver minute quantities of the gas hydrogen sulphide to the mitochondria in cells and help the old or damaged cells to generate the ‘energy’ needed for survival and to reduce senescence.

In the samples used, the number of senescent cells — older cells that have deteriorated and stopped dividing — was reduced by up to 50 per cent.

The team also identified two splicing factors — a component of cells — that play a key role in when and how endothelial cells become senescent.

Continue reading “Compounds AP39, AP123, RT01 may reverse ageing in human cell: Study” »