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In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their original healthy size, as is typically seen in aged and senescent cells.

They demonstrate that in enlarged yeast and human cells, RNA and protein biosynthesis does not scale in proportion to the additional cell size, which then leads to a dilution of the cytoplasm. This phenomenon is also present in senescent cells, which display similar traits to those of large cells.

The research team concludes that the maintenance of a cell type-specific DNA-to-cytoplasm ratio is essential for the majority of cellular functions, and when cellular growth changes this ratio, it encourages cells to become senescent.

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The known Universe just got a lot bigger.

A new map of the night sky published Tuesday charts hundreds of thousands of previously unknown galaxies discovered using a telescope that can detect light sources optical instruments cannot see. Current latest trending Philippine headlines on science, technology breakthroughs, hardware devices, geeks, gaming, web/desktop applications, mobile apps, social media buzz and gadget reviews.

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The Centers for Disease Control and Prevention just issued a new update to its ongoing investigation of a months-long Salmonella outbreak linked to turkey products. The update, which is the first since mid December of last year, adds over 60 new confirmed cases of Salmonella infection to the 200+ cases that were already logged.

A total of 279 cases have now been confirmed across 41 states, with over 100 hospitalized patients and one death resulting from the outbreak. Unfortunately, the bulletin brings more bad news as there’s still been no confirmed source of the Salmonella, and the investigation remains active.

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Biological membranes, and man-made variants, consist of amphiphilic molecules, of which soap is an example. These molecules have a head that bonds with water, but a tail that turns away from water. You can imagine that a group of such molecules in water, preferably puts the tails together, and sticks the heads out, towards the water. Similar processes also dominate the creation of membranes. Often they are spherical, like liposomes, so you can, for example, put a medicine in it. And also the ultimate , the cell wall, is constructed in a similar way.

How nano-droplets self-assemble

Until now, the formation of ‘micelles’ was considered to be the first step in membrane formation. A micelle is an extremely small spherical structure (about 100 nanometers) of amphiphilic molecules—all with the tails inwards and the heads outwards. However, researchers at Eindhoven University of Technology discovered a different beginning: the formation of nano-droplets in with a higher concentration of amphiphilic molecules. At the interface of that drop, the amphiphilic molecules, as it were, take each others’ hands: first they form spheres, which then change into cylinders or plates, and then a closed membrane is created that encloses the nano-droplet. With this so-called ‘self-assembly’ process, the droplet has become a liposome.

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