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Human brain organoids are three-dimensional masses of tissues derived from human stem cells that partially recapitulate the characteristics of the human brain. They have promising applications in many fields, from basic research to applied medicine. However, ethical concerns have been raised regarding the use of human brain organoids. These concerns primarily relate to the possibility that brain organoids may become conscious in the future. This possibility is associated with uncertainties about whether and in what sense brain organoids could have consciousness and what the moral significance of that would be. These uncertainties raise further concerns regarding consent from stem cell donors who may not be sufficiently informed to provide valid consent to the use of their donated cells in human brain organoid research.

Javad Shabani is an Associate Professor of Physics and the Director of the Center of Quantum Information Physics. Shabani seeks to investigate quantum technology, the future of quantum computing, and quantum sensing applications.

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Where do we stand with artificial intelligence? Might machines take over our jobs? Can machines become conscious? Might we be harmed by robots? What is the future of humanity? Professor Giorgio Buttazzo of Scuola Superiore Sant’Anna is an expert in artificial intelligence and neural networks. In a recent publication, he provides considered insights into some of the most pressing questions surrounding artificial intelligence and humanity.

A Brief History of Neural Networks and Deep Learning

In artificial intelligence (AI), computers can be taught to process data using neuron-like computing systems inspired by the mechanisms used by the human brain. These so-called neural networks represent a type of machine learning (‘deep learning’) in which interconnected nodes or neurons are able to adapt and learn from data to recognise patterns and solve complex problems.

The ability to study human neurological systems depends on having viable, accurate models of brain function. St. Jude researchers have now created a model for such research by combining thalamic cells and cortical cells derived from human induced pluripotent stem cells.

The thalamocortical system mediates multiple sensory and , such as perception, learning and memory. The researchers developed a model of a primitive human thalamocortical system by maintaining thalamic and cortical cell masses known as organoids in close proximity in a culture dish.

In this model, the neurons in both organoids develop and grow long-ranging processes (axons) that extend to the opposite organoid and form functional connections (synapses). The researchers determined that when these synapses are stimulated, they undergo long-term strengthening and weakening of their electrical signals, which is the hallmark of , a process that underlies certain forms of learning and memory.