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Leading The Next Wave Of Innovation In Drug Discovery, To Modulate Any Target, Every Time — Dr. P. Ryan Potts, Ph.D., VP and Head, Induced Proximity Platform, Amgen.

Dr. Ryan Potts, Ph.D. is Vice President and Head, Induced Proximity Platform at Amgen (https://www.amgen.com/science/researc…) which is focused on novel ways to bring two or more molecules in close proximity to each other to tackle drug targets that are currently considered “undruggable.” He also leads Amgen’s Research \& Development Postdoctoral Fellows Program (https://www.amgen.com/science/scienti…).

Dr. Potts obtained his B.S. in Biology from the University of North Carolina and his Ph.D. in Cell and Molecular Biology from UT Southwestern in 2007. In 2008 he was awarded the Sara and Frank McKnight junior faculty position at UT Southwestern Medical Center. During this time his lab focused on answering a long-standing question in cancer biology regarding the cellular function of cancer-testis antigen (CTAs) proteins. In 2011 he was appointed Assistant Professor in the Departments of Physiology, Pharmacology, and Biochemistry at UT Southwestern Medical Center. His lab’s work defined a function for the enigmatic MAGE gene (Melanoma Antigen Gene) family in protein regulation through ubiquitination.

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Single-photon detectors built from superconducting nanowires have become a vital tool for quantum information processing, while their superior speed and sensitivity have made them an appealing option for low-light imaging applications such as space exploration and biophotonics. However, it has proved difficult to build high-resolution cameras from these devices because the cryogenically cooled detectors must be connected to readout electronics operating at room temperature. Now a research team led by Karl Berggren at the Massachusetts Institute of Technology has demonstrated a superconducting electronics platform that can process the single-photon signals at ultracold temperatures, providing a scalable pathway for building megapixel imaging arrays [1].

The key problem with designing high-resolution cameras based on these superconducting detectors is that each of the sensors requires a dedicated readout wire to record the single-photon signals, which adds complexity and heat load to the cryogenic system. Researchers have explored various multiplexing techniques to reduce the number of connections to individual detectors, yielding imaging arrays in the kilopixel range, but further scaling will likely require a signal-processing solution that can operate at ultralow temperatures.

Berggren and his collaborators believe that the answer lies in devices called nanocryotrons (nTrons), which are three-terminal structures made from superconducting nanowires, just like the single-photon detectors are. Although nTrons do not deliver the same speed and power of superconducting electronics based on Josephson junctions, the researchers argue that these shortcomings are not a critical problem in photon-sensing applications, where the detectors are similarly limited in speed and power. The nTrons also offer several advantages over Josephson junctions: they operate over a wider range of cryogenic temperatures, they don’t require magnetic shielding, and they exploit the same fabrication process as that used for the detectors, allowing for easy on-chip integration.

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Researchers at TMOS, the ARC Center of Excellence for Transformative Meta-Optical Systems, and their collaborators at RMIT University have developed a new 2D quantum sensing chip using hexagonal boron nitride (hBN) that can simultaneously detect temperature anomalies and magnetic field in any direction in a new, groundbreaking thin-film format.

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Future optical communication and signal processing systems will require high-volume optical links, wherein photonic integrated devices play a key role. Si photonics is currently among the most advanced techniques for realizing low-cost PIC. However, despite their enormous potential, there remain basic restraints on light modulation in SOI waveguides. The absence of a linear EO coefficient is challenging because of the crystal structure of Si.

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Helical foldamers are a class of artificial molecules that fold into well-defined helical structures like helices found in proteins and nucleic acids. They have garnered considerable attention as stimuli-responsive switchable molecules, tuneable chiral materials, and cooperative supramolecular systems due to their chiral and conformational switching properties.

Double-helical foldamers exhibit not only even stronger chiral properties but also , such as the transcription of chiral information from one chiral strand to another without chiral properties, enabling potential applications in higher-order structural control related to replication, like nucleic acids.

However, the artificial control of the chiral switching properties of such artificial molecules remains challenging due to the difficulty in balancing the dynamic properties required for switching and stability. Although various helical molecules have been developed in the past, reversal of twist direction in double-helix molecules and supramolecules has rarely been reported.

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