“Paul and Laura have made huge contributions to the biomedical gerontology field in recent years. Their work focuses on the characterisation and alleviation of the aspects of aging that are driven by DNA damage. At UA2019, their talks will describe their recent advances in the mechanistic understanding of DNA damage, aided by spectacularly good mouse models, and also their identification of natural products with potent senolytic activity”, says Aubrey de Grey.
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The basics of heart health have been drilled into our brains: Eat less saturated fat. Keep moving. Know your “numbers” for cholesterol, blood pressure and BMI.
But what about that brain itself? Although life expectancy has more than doubled since 1900, our “mindspan” — how long we stay cognitively healthy — hasn’t kept pace.
In an extraordinary milestone procedure, scientists in the UK have performed the first gene therapy operation aimed at stopping progression of the most common cause of vision loss. The success of the procedure is yet to be determined, however the scientists suggest this one-off operation could be performed early in the degeneration process and essentially halt the disease in its tracks.
A NASA camera aboard the Deep Space Climate Observatory (DSCOVR) satellite captured a unique view of the moon as it moved in front of the sunlit side of Earth last month. The series of test images shows the fully illuminated ‘dark side’ of the moon that is never visible from Earth. The images were captured by NASA’s Earth Polychromatic Imaging Camera (EPIC), a four megapixel CCD camera and telescope on the DSCOVR satellite orbiting 1 million miles from Earth. From its position between the sun and Earth, DSCOVR conducts its primary mission of real-time solar wind monitoring for the National Oceanic and Atmospheric Administration (NOAA). EPIC maintains a constant view of the fully illuminated Earth as it rotates, providing scientific observations of ozone, vegetation, cloud height and aerosols in the atmosphere. Once EPIC begins regular observations next month, the camera will provide a series of Earth images allowing study of daily variations over the entire globe. About twice a year the camera will capture the moon and Earth together as the orbit of DSCOVR crosses the orbital plane of the moon. These images were taken between 12:50 p.m. and 5:45 p.m. PDT on July 16, showing the moon moving over the Pacific Ocean near North America. The North Pole is in the upper left corner of the image, reflecting the orbital tilt of Earth from the vantage point of the spacecraft. EPIC’s ‘natural color’ images of Earth are generated by combining three separate monochrome exposures taken by the camera in quick succession. EPIC takes a series of 10 images using different narrowband spectral filters — from ultraviolet to near infrared — to produce a variety of science products. The red, green and blue channel images are used in these color images. Combining three images taken about 30 seconds apart as the moon moves produces a slight but noticeable camera artifact on the right side of the moon. Because the moon has moved in relation to the Earth between the time the first (red) and last (green) exposures were made, a thin green offset appears on the right side of the moon when the three exposures are combined. This natural lunar movement also produces a slight red and blue offset on the left side of the moon in these unaltered images. The lunar far side lacks the large, dark, basaltic plains, or maria, that are so prominent on the Earth-facing side. The largest far side features are Mare Moscoviense in the upper left and Tsiolkovskiy crater in the lower left. A thin sliver of shadowed area of moon is visible on its right side.
Autologous induced pluripotent stem cells (iPSCs) constitute an unlimited cell source for patient-specific cell-based organ repair strategies. However, their generation and subsequent differentiation into specific cells or tissues entail cell line-specific manufacturing challenges and form a lengthy process that precludes acute treatment modalities. These shortcomings could be overcome by using prefabricated allogeneic cell or tissue products, but the vigorous immune response against histo-incompatible cells has prevented the successful implementation of this approach. Here we show that both mouse and human iPSCs lose their immunogenicity when major histocompatibility complex (MHC) class I and II genes are inactivated and CD47 is over-expressed. These hypoimmunogenic iPSCs retain their pluripotent stem cell potential and differentiation capacity. Endothelial cells, smooth muscle cells, and cardiomyocytes derived from hypoimmunogenic mouse or human iPSCs reliably evade immune rejection in fully MHC-mismatched allogeneic recipients and survive long-term without the use of immunosuppression. These findings suggest that hypoimmunogenic cell grafts can be engineered for universal transplantation.
However, a shortage of hi-tech research capacity in the region is turning into a hindrance, according to analysts, with most of China’s top-notch science and engineering schools located in the northern and eastern provinces. Although Hong Kong has several universities in the world’s top 100, only a few of them have a science and technology focus.
China’s ‘Greater Bay Area’ plan aims to erase barriers between cities in the region in terms of policy, financing, logistics and talent.
Barely a week goes by without reports of some new mega-hack that’s exposed huge amounts of sensitive information, from people’s credit card details and health records to companies’ valuable intellectual property. The threat posed by cyberattacks is forcing governments, militaries, and businesses to explore more secure ways of transmitting information.
Get Singularity University’s innovation framework to enable powerful future growth. Christine Kelly, Managing Director, Innovation & Design at SUfour key steps that enable organizations to leap from ideation to delivering breakout solutions and growth that will drive sustained success.
Hutchinson–Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging. The major underlying genetic cause is a substitution mutation in the gene coding for lamin A, causing the production of a toxic isoform called progerin. Here we show that reduction of lamin A/progerin by a single-dose systemic administration of adeno-associated virus-delivered CRISPR–Cas9 components suppresses HGPS in a mouse model.
