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In “Avengers: Endgame,” Tony Stark warned Scott Lang that sending him into the quantum realm and bringing him back would be a “billion-to-one cosmic fluke.”

In reality, shrinking a to a nanometer-sized point to spy on quantum-scale -matter interactions and retrieving the information is not any easier. Now, engineers at the University of California, Riverside, have developed a new technology to tunnel light into the quantum realm at an unprecedented efficiency.

In a Nature Photonics paper, a team led by Ruoxue Yan, an assistant professor of chemical and , and Ming Liu, an assistant professor of electrical and computer engineering, describe the world’s first portable, inexpensive, optical nanoscopy tool that integrates a glass optical fiber with a silver nanowire condenser. The device is a high-efficiency round-trip light tunnel that squeezes visible light to the very tip of the condenser to interact with molecules locally and send back information that can decipher and visualize the elusive nanoworld.

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Dielectric laser accelerators (DLAs) provide a compact and cost-effective solution to this problem by driving accelerator nanostructures with visible or near-infrared (NIR) pulsed lasers, resulting in a 10,000 times reduction of scale. Current implementations of DLAs rely on free-space lasers directly incident on the accelerating structures, limiting the scalability and integrability of this technology. Researchers present the first experimental demonstration of a waveguide-integrated DLA, designed using a photonic inverse design approach. These on-chip devices accelerate sub-relativistic electrons of initial energy 83.4 keV by 1.21 keV over 30 µm, providing peak acceleration gradients of 40.3 MeV/m. This progress represents a significant step towards a completely integrated MeV-scale dielectric laser accelerator.

Dielectric laser accelerators have emerged as a promising alternative to conventional RF accelerators due to the large damage threshold of dielectric materials the commercial availability of powerful NIR femtosecond pulsed lasers, and the low-cost high-yield nanofabrication processes which produce them. Together, these advantages allow DLAs to make an impact in the development of applications such as tabletop free-electron-lasers, targeted cancer therapies, and compact imaging sources.

They have designed and experimentally verified the first waveguide-integrated DLA structure. The design of this structure was made possible through the use of photonics inverse design methodologies developed by the team members. The fabricated and experimentally demonstrated devices accelerate electrons of an initial energy of 83.4 keV by a maximum energy gain of 1.21 keV over 30 µm, demonstrating acceleration gradients of 40.3 MeV/m. In this integrated form, these devices can be cascaded to reach MeV-scale energies, capitalizing on the inherent scalability of photonic circuits. Future work will focus on multi-stage demonstrations, as well as exploring new design and material solutions to obtain larger gradients.

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Research by neuroscientists at the University of Chicago shows how short-term, working memory uses networks of neurons differently depending on the complexity of the task at hand.

The researchers used modern artificial intelligence (AI) techniques to train computational neural networks to solve a range of complex behavioral tasks that required storing information in short term . The AI networks were based on the biological structure of the brain and revealed two distinct processes involved in short-term memory. One, a “silent” process where the brain stores short-term memories without ongoing neural activity, and a second, more active process where circuits of fire continuously.

The study, led by Nicholas Masse, Ph.D., a senior scientist at UChicago, and senior author David Freedman, Ph.D., professor of neurobiology, was published this week in Nature Neuroscience.

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Why do we feel listless when we are recovering from an illness? The answer is, apparently, that low-grade chronic inflammation interferes with the dopaminergic signaling system in the brain that motivates us to do things.

This was reported in a new paper published in the journal Trends in Cognitive Sciences.

The research carried out at Emory University explains the links between the reduced release of dopamine in the brain, the motivation to do things, and the presence of an inflammatory reaction in the body. It also presents the possibility that this is part of the body’s effort to optimize its energy expenditure during such inflammatory episodes, citing evidence gathered during their study.

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Alphabet, Inc., the parent company of Google, plans to develop a life-long gene therapy for heart disease, the leading cause of death for men and women in the U.S.

Attaining this lofty goal will be the job of Alphabet’s gene-editing start-up, Verve Therapeutics, and Google’s life science start-up, Verily.

This month, Google’s venture fund, GV, partnered with three other funds to launch Verve Therapeutics with $58.5 million in Series A funding. The company’s scientific founders include Dr. Sekar Kathiresan (CEO), Dr. Kiran Musunuru (chief scientific adviser) and Dr. J. Keith Joung (strategic adviser).

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