Blog – Page 9583

A total knee replacement is usually the result of the cartilage within the joint wearing out due to arthritis. Such surgeries are difficult to perform, require a good deal of rehabilitation, and too often result in sub-optimal outcomes. An implantable shock absorber has now been implanted for the first time in the United States to test whether it can delay the need for total knee replacements, and maybe even avoid such procedures completely in many patients.

The Calypso Knee System was developed by Moximed, a company based in Fremont, California, and surgeons at The Ohio State University Wexner Medical Center are the first to try it out in the U.S. The device attaches to the sides of the femur and tibia bones, away from the joint itself and therefore doesn’t alter the anatomy of the fragile joint.

Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how. They found in mice that fever alters surface proteins on immune cells like lymphocytes to make them better able to travel via blood vessels to reach the site of infection. Their work appears on January 15 in the journal Immunity.

“One good thing about fever is that it can promote lymphocyte trafficking to the site of infection, so you will have more immune cells in the infected region that will get rid of the pathogen,” says Shanghai Institute of Biochemistry and Cell Biology (SIBCB) Professor and senior author JianFeng Chen.

To get to an infection, white blood cells need to adhere to the blood vessel and then transmigrate into the infected tissue or lymph node. During this step, molecules known as integrins are expressed on the surface of lymphocytes. Integrins are cell adhesion molecules that control lymphocyte trafficking during inflammation.