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I am writing this shortly after returning from the third edition of RAADfest, a conference created two years ago by a team led by Jim Strole. I go to a lot, I mean a lot, of conferences, not least because outreach is such a big part of my role in our crusade. But I think this is the first time I have chosen to devote an editorial to one. You may wonder what’s so special.

Well, RAADfest is … not your typical conference. Its organizers—Strole and his team, most notably his partner Bernadeane—have, for a couple of decades, led a group in Arizona named “People Unlimited”, which has acquired a reputation—and, I have to report, a well-deserved one—for, let’s say, placing excessive emphasis on the principle that ‘‘where there’s a will there’s a way’’ in relation to the defeat of aging (Yeah, I can still do classic British understatement when I try). Accordingly, when they first let it be known that they planned to do something bigger, the initial reaction was decidedly mixed. I don’t know how many credentialed biogerontologists declined speaking invitations, but only a few of us accepted—and of those, as I recall, only the perennially fearless Michael Rose was a university professor. I myself, though happy to lend my support to this new initiative as a speaker, was rather more diffident in response to Strole’s entreaties to promote the event through my outreach channels.

But the doubters were wrong—very wrong. The event was a storming success, in terms of both attendance—Strole had secured significant sponsorship from the Life Extension Foundation under the expectation of a budgetary shortfall but was actually able to give it back, yes you read that correctly—and also content, which, while being necessarily a little light on science given the paucity of scientist speakers, was coherent, rousing, and informative.

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Stressful life events most likely contribute to autoimmune diseases, but scientists don’t have a deep understanding of the underlying chain of events. A study on mice published this week in mSystems suggests that the gut microbiota may play a significant role in that connection. Researchers found that the onset of stress caused changes in the intestinal bacteria that, in turn, stimulated the activity of immune cells in a way that increased the likelihood that the body would a…


Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.

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Dark matter is an unknown type of matter present in the universe that could be of particle origin. One of the most complete theoretical frameworks that includes a dark matter candidate is supersymmetry. Many supersymmetric models predict the existence of a new stable, invisible particle called the lightest supersymmetric particle (LSP), which has the right properties to be a dark matter particle.

The ATLAS Collaboration at CERN has recently reported two new results on searches for an LSP that exploited the experiment’s full Run 2 data sample taken at 13 TeV proton-proton collision energy. The analyses looked for the pair production of two heavy supersymmetric particles, each of which decays to observable Standard Model particles and an LSP in the detector.

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A new finding puts the half-life of xenon 124 close to 18 sextillion years.

That’s 18,000,000,000,000,000,000,000.

Existing theory predicts the isotope’s radioactive decay has a half-life that surpasses the age of the universe “by many orders of magnitude,” but no evidence of the process has appeared until now.

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