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University of Sydney research provides new evidence that nanoparticles, which are present in many food items, may have a substantial and harmful influence on human health.

The study investigated the health impacts of food additive E171 (titanium dioxide nanoparticles) which is commonly used in high quantities in foods and some medicines as a whitening agent. Found in more than 900 food products such as chewing gum and mayonnaise, E171 is consumed in high proportion everyday by the general population.

Published in Frontiers in Nutrition, the mice study found that consumption of food containing E171 has an impact on the gut microbiota (defined by the trillions of bacteria that inhabit the gut) which could trigger diseases such as inflammatory bowel diseases and colorectal cancer.

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The human body has powerful healing abilities. But treating brain disorders is no easy task, as brain cells—neurons—have limited ability to regenerate. Nonetheless, stem cells are a form of natural backup, a vestige of our days as still-developing embryos.

The difficulty is that with age, neural stem cells ‘fall asleep’ and become harder to wake up when repairs are needed. Despite efforts to harness these cells to treat neurological damage, scientists have until recently been unsuccessful in decoding the underlying ‘sleep’ mechanism.

Now, researchers at Kyoto University studying brain chemistry in mice have revealed the ebb and flow of gene expression that may wake neural stem cells from their slumber. These findings, which may also apply to stem cells elsewhere in the body, were recently published in the journal Genes & Development.

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People will stop complaining about EV range the minute fast charging is a reality, and new startup Piëch reckons it’s got the goods to deliver an 80 percent charge on a 311-mile (500 km) range battery in four minutes, 40 seconds, which is vastly quicker than anything else on the market. Why not just launch the battery, then?

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As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell. Researchers at the University of Basel in Switzerland exploited this critical phase, known as an epithelial-mesenchymal transition (EMT), to coax breast cancer cells in mice to turn into harmless fat cells. The proof-of-concept study appears January 14 in the journal Cancer Cell.

“The breast cancer cells that underwent an EMT not only differentiated into fat cells, but also completely stopped proliferating,” says first author Gerhard Christofori, professor of biochemistry at the University of Basel. What’s more, the did not metastasize. “As far as we can tell from long-term culture experiments, the cancer cells-turned-fat cells remain fat cells and do not revert back to breast cancer cells,” he says.

Epithelial cells undergoing EMT regress from terminally differentiated cells to a more immature state reminiscent of stem cells. EMT is essential for embryonic development, during which stem cells differentiate into a variety of cell types throughout the body, and for tissue regeneration such as wound healing. EMT and the inverse process, mesenchymal-epithelial transition (MET), are implicated in cancer’s ability to metastasize.

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