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In breast cancer, there are cases of women and men whose cancer returns in their bones 20–30 years after they were treated for their primary disease and thought they were cancer-free. This phenomenon always puzzled Jefferson researcher Karen Bussard, Ph.D. How is it possible that breast cancer cells from a primary tumor are able to reach the bones when a patient is deemed “cancer-free” after treatment? What was happening in bones that allowed the cancer cells to remain there for up to 30 years, alive but in a sleeping state, only to re-awaken decades later? In a step towards answering these questions, Dr. Bussard recently discovered a type of bone cell that can subdue cancer cells, slowing their growth, even in one of the most aggressive types of breast cancer: triple negative.

The results, published in Breast Cancer Research, raise intriguing questions about how these exert their sleep-inducing influence, and whether it’s possible to replicate and permanently turn cancers dormant.

“Cancer has this uncanny ability to turn other cell types it comes in contact with to the cell’s advantage,” says Dr. Bussard, Assistant Professor of Cancer Biology at Thomas Jefferson University and a researcher at the Sidney Kimmel Cancer Center—Jefferson Health. “For example, cancer cells can turn the immune cells that should kill it, into its own guards. However, we have now found a population of bone cells that not only resists, but subdues the cancer. It’s fascinating.”

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The scenario military thinkers propose would double the number of jet fighters in a typical battle formation from four to eight. But instead of the additional aircraft being identical to an F-35 joint strike fighter, or F-15E Strike Eagle, they are low-cost, unmanned jets.

One might carry extra air-to-air missiles. Another may only have a sensor suite to boost situational awareness for the pilots in the traditional aircraft.

Whatever their payload, the enemy has to contend with double the number of targets on their radars. They have multiple “dilemmas” in front of them, giving U.S. forces an asymmetric advantage.

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A recent article, published in the Oxford journal Brain, categorizes and draws attention to an age-related disease that impacts the brain yet is widely unknown, even among scientists: limbic-predominant age-related TDP-43 encephalopathy (LATE) [1].

The symptoms of this disease are similar to those of Alzheimer’s disease. It causes cognitive impairment and, when presenting alongside Alzheimer’s disease, can lead to even faster degeneration along with heightened agitation and aggression.

This new disease has been found to impact very specific areas of the brain – generally traveling vertically through the brain, it degenerates areas partly responsible for emotions, memory, and language, influencing different areas depending on its stage.

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I’m excited to share my new #transhumanism article out at Metro, on of UK’s largest sites. It’s part of their #FutureofEverything series. Check out the artwork too:

Whatever science transhumanists want to use to become a better species, overcoming biological death is the movement’s primary goal.

Most deaths in the world are caused by ageing and disease. Approximately 150,000 people die every day on planet Earth, causing devastating loss to loved ones and communities.

I think the first step in getting this figure to decrease is for governments around the world to declare ageing a disease.

Continue reading “Death could soon become a curable disease” | >

I’m at the Humans to Mars Summit in Washington D.C. sharing about NASA’s plans to use the Moon as a proving ground for our ultimate goal of sending humans to Mars. Watch:

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“We looked at a group of tiny, green bacteria called Prochlorococcus which is the most abundant photosynthetic organism on Earth, with a global population of around three octillion (~1027) individuals,” says Sasha.

Ten per cent of the oxygen we breathe comes from just one kind of bacteria in the ocean. Now laboratory tests have shown that these bacteria are susceptible to plastic pollution, according to a study published in Communications Biology.

“We found that exposure to chemicals leaching from interfered with the growth, photosynthesis and oxygen production of Prochlorococcus, the ocean’s most abundant photosynthetic bacteria,” says lead author and Macquarie University researcher Dr. Sasha Tetu.

“Now we’d like to explore if is having the same impact on these microbes in the ocean.”

Continue reading “It’s not just fish, plastic pollution harms the bacteria that help us breathe” | >

While old business clans continue to dominate India’s rich lists, a tenfold expansion in its economy since its opening in the 1990s has spawned new tycoons in fields like technology. The number of billionaires in India more than doubled to 119 between 2013 and 2018, according to Knight Frank. And the country will lead the global growth in ultrahigh net worth individuals, with its numbers rising 39 percent to 2,697 by 2023, the researcher estimates.

India is going through one of the greatest periods of wealth creation — and destruction — all at the same time.

A new breed of self-made entrepreneurs is vaulting into the ranks of the wealthy, offsetting billions lost by debt-burdened industrialists and members of the country’s old dynasties. The changes are set to help India’s ultra-rich population grow at the world’s fastest pace.

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