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Dr. Oliver Medvedik and guests will be taking a look at the recent human trial of Urolithin A, a metabolite produced by microflora and an active ingredient in pomegranates which is linked to increased levels of mitophagy in aged animals. Join us at 13:00 EDT on our Facebook channel where we will be livestreaming the show and discussing this interesting publication.

Link to Paper: https://www.nature.com/articles/s42255-019-0073-4

Literature.

Nature asked researchers and other stakeholders what hurdles remain before heritable gene editing could become acceptable as a clinical tool. Although some scientific challenges are probably surmountable, approval on a grand scale is likely to require changes to how clinical trials are run, as well as a broader consensus about the technology.


Efforts to make heritable changes to the human genome are fraught with uncertainty. Here’s what it would take to make the technique safe and acceptable.

CLEVELAND — The Cleveland Clinic has joined other top hospitals in North America and can now offer in utero surgery. The hospital announced Wednesday that after more than a year of preparations they have successfully completed Northern Ohio’s first ever surgery on a fetus inside the uterus to repair spina bifida.

“The operation on the fetus in the uterus, I’m directing and in charge of, and the guidance of where we should open the uterus, the exposure of the baby,” said Dr. Darrell Cass, Director of Fetal Surgery in the Cleveland Clinic’s Fetal Center.

Cass and a team of more than a dozen other specialists including pediatric neurosurgeons, a fetal cardiologist and pediatric anesthesiologists performed the surgery on a nearly 23-week fetus with the birth defect spina bifida in February.

I had a little more invested in BCI.


Brain-machine interface—once the stuff of science fiction novels—is coming to a computer near you. The only question is: How soon? While the technology is in its infancy, it is already helping people with spinal cord injuries. Our authors examine its potential to be the ultimate game changer for any number of neurodegenerative diseases, as well as behavior, learning, and memory.