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In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have used CRISPR to uncover which gene fusions are critical for the growth of cancer cells. The team also identified a new gene fusion that presents a novel drug target for multiple cancers, including brain and ovarian cancers.

The results, published today (16 May) in Nature Communications, give more certainty for the use of specific to diagnose and guide the treatment of patients. Researchers suggest existing drugs could be repurposed to treat some people with pancreatic, breast and lung cancers, based on the gene fusions found in their tumours.

Gene fusions, caused by the abnormal joining of two otherwise different , play an important role in the development of . They are currently used as diagnostic tools to predict how particular cancer patients will respond to drugs, as well as prognostics, to estimate the outcome for a patient given the best possible care. They are also the targets of some of the latest targeted treatments for cancer.

From Watson to Sophia, who are the artificially intelligent robot personas of today, and what can they tell us about our future?

Siri. Alexa. Cortana. These familiar names are the modern-day Girl Fridays making everyone’s life easier. These virtual assistants powered by artificial intelligence (AI) bring to life the digital tools of the information age. One of the subtle strategies designers use to make it easier for us to integrate AI into our lives is “anthropomorphism” - the attribution of human-like traits to non-human objects. However, the rise of AI with distinct personalities, voices, and physical forms is not as benign as it might seem. As futurists who are interested in the impacts of technology on society, we wonder what role human-like technologies play in achieving human-centred futures.

For example, do anthropomorphized machines enable a future wherein humanity can thrive? Or, do human-like AIs foreshadow a darker prognosis, particularly in relation to gender roles and work? This article looks at a continuum of human-like personas that give a face to AI technology. We ask: what does it mean for our collective future that technology is increasingly human-like and gendered? And, what does it tell us about our capacity to create a very human future?

The Women of AI

One of the most important observations we want to convey is that the typical consumer-facing AI persona is highly feminine and feminized. There are several robots and AI that take a female form. The examples below show the sheer breadth of applications where a feminine persona and voice are deliberately used to help us feel comfortable with increasingly invasive technology:

Magnetic levitation keyboards have been around for a while, but they’ve never really taken off, or floated our boats, or attracted much atten… Anyway, a Taiwanese manufacturer called Darfon is persevering with the idea, and it’s discovered that maglev keys, which rest on opposing magnets instead of mushy membranes or mechanical switches, can make laptop keyboards significantly thinner. Unfortunately, according to a CNET journalist who played with a couple of prototypes at Computex, the keys can be hard to type on if skinniness is taken to the extreme. Then again, there’s scope to change the resistance of the keyboard electronically to suit your preference, and Darfon claims it has already received orders from laptop makers who are targeting launches later this year. If that’s true, perhaps the technology isn’t so repellant after all.

[Image credit: Aloysius Low / CNET].

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Tunneling, a key feature of quantum mechanics, is when a particle that encounters a seemingly insurmountable barrier passes through it, ending up on the other side. A series of experiments carried out by physicists from Griffith University, Lanzhou University, the Australian National University, Drake University and Korea’s Institute for Basic Science has definitively determined the tunneling delay, which is also the time it takes for an electron to get out or ionize from a hydrogen atom.

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DENVER — Researchers have developed a new, unspeakably dangerous, and incredibly slow method of crossing the universe. It involves wormholes linking special black holes that probably don’t exist. And it might explain what’s really going on when physicists quantum-teleport information from one point to another — from the perspective of the teleported bit of information.

Daniel Jafferis, a Harvard University physicist, described the proposed method at a talk April 13 here at a meeting of the American Physical Society. This method, he told his assembled colleagues, involves two black holes that are entangled so that they are connected across space and time.

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