Lifeboat Foundation

Understanding the factors that control aging has been one of humanity’s endless pursuits, from the mystical fountain of youth to practical healthful regimens to prolong life expectancy.

A team of scientists at the University of California San Diego has helped decipher the dynamics that control how our cells age, and with it implications for extending human longevity. As described in a study published in the Proceedings of the National Academy of Sciences, a group led by biologist Nan Hao employed a combination of technologies in engineering, computer science and biology to analyze molecular processes that influence aging.

As cells age, damage in their DNA accumulates over time, leading to decay in normal functioning and eventually resulting in death. A natural biochemical process known as “chromatin silencing” helps protect DNA from damage. The silencing process converts specific regions of DNA from a loose, open state into a closed one, thus shielding DNA regions. Among the molecules that promote silencing is a family of proteins—broadly conserved from bacteria to humans—known as sirtuins. In recent years, chemical activators of sirtuins have received much attention and are being marketed as nutraceuticals to aid chromatin silencing in the hopes of slowing the aging process.

Continue reading “Scientists decipher mechanisms underlying the biology of aging” »

A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes — a specific virus and two specific types of bacteria — are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research — and more importantly, for clinical trials of anti-microbial and related agents to treat the disease.

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial — despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

Continue reading “Landmark editorial identifies microbes as major cause of Alzheimer’s Disease” »

The rise of artificial intelligence threatens to eliminate jobs once considered impossible to automate. One series of papers by Oxford researchers ranks jobs by their estimated susceptibility to automation. Among those most rated likely to vanish – because they involve work that AI can increasingly accomplish less expensively – are real estate brokers, insurance claims adjusters and sports referees. Could anything good come of mass unemployment?

History tells us that when technology squeezes people out of jobs, they revolt. Industrialization in 19th-century England, for example, gave rise to Luddite activism. Unfortunately, history also suggests that protests of the marginalized don’t solve the underlying problem. The British Army suppressed the Luddites; the government passed laws to protect factory equipment and industrialization marched on. As Marx went on to theorize, in a capitalist society, the government is co-opted by the wealthy classes.

What happens, though, when that skilled upper class is itself put out of a job? That’s the question that mass AI-based unemployment would pose. What would happen when well-educated lawyers, journalists, bureaucrats, corporate managers and other creative-class knowledge workers can’t find work? Could the rise of AI lead to a white-collar rebellion?

Continue reading “Will AI job-stealing robots lead to a human revolution?” »

As luck would have it, we may be on the verge of another revolution in miniaturization, this time through nanoelectronics.

Creating electronics at the nanoscale is difficult and has faced limitations but those limitations may be a thing of the past. Researchers from the National University of Singapore have developed a “converter” for nanoelectronic devices that could allow them to use plasmons for data processing.

Continue reading “Unbelievably Fast Processing for Nanoelectronics” »

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Robot workers will improve life for everyone, not just the rich, according to Tim O’Reilly.

Thank you to everyone who took part in Longevity Month 2017!

Over the past few years, there has been a tradition of longevity researchers and activists around the world to organize events on or around October 1 — the UN International Day of Older Persons, or Longevity Day. In recent years, this has been extended to include the entire month of October as a Longevity Month, in which activists organize various activities and events to raise awareness for aging research.

This year, we have continued the tradition with our Longevity Month “I am the Lifespan” event, where people tell us their stories and how they got interested in aging research and doing something about age-related diseases. We are pleased to say that the response to our Longevity Month event has been a great success, with lots of videos being sent in by people from the community. We have been showcasing them on our Facebook event page during the last few weeks, and as the event has now ended, we wanted to share a few more with you and tell you a little bit about some of the participants.

Continue reading “I Am The Lifespan – Thank You for Making Longevity Month 2017 a Success” »

A walking robot is all fun and games until it starts chasing you.

Building solar and wind farms has started to become a cheaper proposition than running aging coal and nuclear generators in parts of the U.S., according to financial adviser Lazard Ltd.

Alphabet chairman Eric Schmidt says the US is at risk of falling behind in the race to develop cutting-edge artificial intelligence. Speaking at a tech summit organized by national security think tank CNAS, Schmidt predicted that America’s lead in the field would continue “over the next five years” before China catches up “extremely quickly.”

“They are going to use this technology for both commercial and military objectives, with all sorts of implications,” said Schmidt, referencing a Chinese policy document outlining the country’s ambition to become the global leader in AI by 2030. Schmidt reiterated several familiar talking points in this debate, primarily that the US is failing to invest in basic research, and that a restrictive immigration policy hobbles the country’s ability to attract AI talent from overseas.

“Some of the very best people are in countries that we won’t let into America. Would you rather have them building AI somewhere else, or rather have them here?” said Schmidt. “Iran produces some of the top computer scientists in the world, and I want them here. To be clear, I want them working for Alphabet and Google!”

Continue reading “Google’s former CEO says US could fail in the AI competition with China” »