Lifeboat Foundation

Crispre cas 9.

A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. Targeted manipulation of neural circuits often depends on genetic dissection, and use of this technique has been restricted to only a few model species, limiting its application in comparative research. However, ongoing advances in genomics make genetic dissection attainable in a growing number of species. To demonstrate the potential of comparative gene editing approaches, we developed a viral-mediated CRISPR/Cas9 strategy that is predicted to target the oxytocin receptor (Oxtr) gene in 80 rodent species. This strategy specifically reduced OXTR levels in all evaluated species (n = 6) without causing gross neuronal toxicity. Thus, we show that CRISPR/Cas9-based tools can function in multiple species simultaneously. Thereby, we hope to encourage comparative gene editing and improve the translatability of neuroscientific research.

The development of comparative gene editing strategies improves the translatability of animal research.

If I were a brilliant physicist, I would have written this.

Learn more about differential equations (and many other topics in maths and science) on Brilliant using the link https://brilliant.org/sabine. You can get started for free, and the first 200 will get 20% off the annual premium subscription.

Continue reading “I don’t believe in free will. This is why” »

Vice President of AI & Quantum Computing, Paul Smith-Goodson gives his analysis of quantum machine learning models and IonQ’s strategy to make it a reality.

Usually, the two characterizations of a material are mutually exclusive: something is either stiff, or it can absorb vibrations well—but rarely both. However, if we could make materials that are both stiff and good at absorbing vibrations, there would be a whole host of potential applications, from design at the nanoscale to aerospace engineering.

A team of researchers from the University of Amsterdam has now found a way to create materials that are stiff, but still good at absorbing vibrations—and equally importantly, that can be kept very light-weight.

Continue reading “Buckle up: A new class of materials is here” »

A scientist claims he has increased his lifespan by 20 percent after living 93 days underwater.

Joseph Dituri, 55, a retired Naval officer, has been living inside a 100-square-foot pod at the bottom of the Atlantic Ocean for 93 days, researching how a pressurized environment impacts the human body.

Continue reading “Scientist living at the bottom of the Atlantic said he has de-aged” »

Ever feel like you need more time? That it’s just flying by you?

And, then, do you ever wish you could reverse it?

A study published in Scientific Reports by an international team of researchers has demonstrated that a time-reversal program on a quantum computer is possible.

A team from NIST and the University of Colorado Boulder have developed a novel device using gallium nitride nanopillars on silicon that significantly improves the conversion of heat into electricity. This could potentially recover large amounts of wasted heat energy, benefiting industries and power grids.

Researchers at the National Institute of Standards and Technology (NIST) have fabricated a novel device that could dramatically boost the conversion of heat into electricity. If perfected, the technology could help recoup some of the heat energy that is wasted in the U.S. at a rate of about $100 billion each year.

Continue reading “Revamping Energy Recovery: New Way To Efficiently Convert Waste Heat Into Electricity” »

The emergence of AI language-modelling tools could end my endeavour as a blogger.

AutoGPT makes writing this blog by me and other contributors seem irrelevant as it does for a whole bunch of human-generated services.

12 years of blood, sweat, and science went into success.