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Novel molecular mechanisms inform targeted therapies for chronic kidney disease

A recent study led by Paul DeCaen, Ph.D., associate professor of Pharmacology, has identified novel molecular mechanisms by which genetic mutations in the PKD2 gene cause the most common form of polycystic kidney disease, according to findings published in the Proceedings of the National Academy of Sciences.

PKD2 encodes an localized to the primary cilia of cells lining the kidney collecting ducts, a series of tubules and ducts that helps achieve electrolyte and fluid balance in the body. Both inherited and acquired mutations in PKD2 are known to cause (ADPKD), a condition characterized by the growth of fluid-filled cysts in the kidneys that can lead to and other serious complications.

According to the National Institute of Diabetes and Digestive and Kidney Diseases, one in 1000 individuals will develop ADPKD and more than 95% of patients carry disease-causing genetic variants in PKD1 or PKD2. However, there are no available therapies that target these disease-causing variants.

SARS-CoV-2 can cause buildup of Alzheimer’s-related peptides in retina

A new Yale study has found a promising target for treating the brain fog that can follow COVID-19 and offers new insight into a hypothesis about the origin of Alzheimer’s disease.

One of the hallmarks of Alzheimer’s disease is the presence of plaque formed by the buildup of amyloid beta peptides (short chains of amino acids) in and around . Some researchers suspect that amyloid beta, which is structurally similar to , protects the brain against bacteria, viruses, parasites, and . Because the tends to lose its integrity in Alzheimer’s disease patients, the accumulation of amyloid beta might be a signal that pathogens are infiltrating the brain.

In a new study published in Science Advances, Yale researchers investigated whether infection by SARS-CoV-2—the virus that causes COVID-19—can trigger Alzheimer’s disease-like amyloid beta buildup, leading to neurological impairments like .

DeepMind’s AlphaGenome Uses AI to Decipher Noncoding DNA for Research, Personalized Medicine

This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger everything from cancer to rare genetic disorders—and potentially revolutionizing personalized medicine

“It’s Like Armoring Your Home”: Breakthrough Coating Transforms Ordinary Windows Into Powerful Energy-Saving Shield for Every Household

IN A NUTSHELL 🌟 Rice University researchers developed a groundbreaking glass coating that reflects heat and reduces energy costs. 🔬 The coating is made from a tough layer of boron nitride and carbon, offering resistance to UV light and temperature swings. 💡 This innovation uses pulsed laser deposition at room temperature, making it cost-effective and.

These microlasers light up your food — and then you can eat them

Scientists have reimagined the meaning of a “light meal,” creating microlasers that use natural products to emit illuminated beams through food. And they’re completely edible. These mini lights, the first demonstration of laser emission from an entirely edible system, could be harnessed for everything from environmental sensors to food safety trackers and bio-barcodes.

Scientists from Slovenia’s Jožef Stefan Institute have successfully created “edible microlasers,” which are exactly what they sound like – tiny optical devices, smaller than a grain of sand, that emit a beam of coherent light like normal lasers. And they’re made out of biocompatible and digestible materials like gelatin, sugar and dyes, including additives already approved by the Food and Drug Administration (FDA), meaning they’re perfectly safe to ingest.

Why, you may ask? Because they’re tiny and safe to eat, with fluorescent compounds such as chlorophyll (from olive oil) and riboflavin (vitamin B2), they could be widely applicable for use in food safety to track supply chain data, detect temperature changes and spoilage, prevent counterfeit goods or even act as QR or bar codes.