Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 8

A new “atlas” developed by researchers at Duke University School of Medicine, University of Tennessee Health Science Center, and the University of Pittsburgh will increase precision in measuring changes in brain structure and make it easier to share results for scientists working to understand neurological diseases such as Alzheimer’s disease.

The tool, the Duke Mouse Brain Atlas, combines microscopic resolution, three-dimensional images from three different techniques to create a detailed map of the entire brain, from large structures down to and circuits.

“This is the first truly three-dimensional, stereotaxic of the mouse brain,” said G. Allan Johnson, Ph.D., Charles E. Putman University Distinguished Professor of Radiology at Duke. He is also professor in the Department of Physics and the Department of Biomedical Engineering.

Read more | >

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition in which affected individuals experience difficulties in social communication and exhibit restricted, repetitive patterns of behavior or interests.

A growing body of research suggests that neurobiological changes, particularly abnormalities in , tiny protrusions on where synapses form, may be a hallmark of ASD. In particular, studies have found an unusually high number of these spines in individuals with autism. This overabundance of synaptic connections could disrupt normal communication pathways in the brain, potentially contributing to the behavioral and cognitive features seen in ASD.

Under normal circumstances, the brain undergoes , a process involving the removal of unnecessary or weak synaptic connections to make way for more efficient neural networks. This pruning is crucial during early development and adolescence.

Read more | >

An investigational gene therapy has successfully restored immune function in all nine children treated with the rare and life-threatening immune disorder called severe leukocyte adhesion deficiency-I, or LAD-I, in an international clinical trial co-led by UCLA.

LAD-I is a genetic condition that affects approximately one in a million people in the world. It is caused by mutations in the gene that produces CD18, a protein that enables to travel from the bloodstream to infection sites.

In the absence of this critical protein, individuals with severe LAD-I—most of whom are diagnosed within their first months of life—are left vulnerable to dangerous, recurrent bacterial and fungal infections. Survival beyond childhood is rare without treatment.

Read more | >

Aiming to reduce recurrent stroke in patients with embolic stroke of unknown source (ESUS), recent trials have compared direct oral anticoagulants (DOACs) to aspirin, but results have been neutral. For example, the ARCADIA trial compared apixaban versus aspirin in patients with ESUS and evidence of atrial cardiopathy, finding no difference. Now, researchers report results of an MRI substudy of ARCADIA, in which patients underwent a baseline and end-of-study MRI. This analysis compares the rate of MRI-detected covert (silent), nonlacunar stroke in the two treatment groups.

Of the 1,015 patients in the parent trial, 310 patients enrolled in the MRI substudy, of whom 174 patients had image quality sufficient for analysis. In these 174 patients (mean age, 66 years; 48% women), the aspirin group had higher rates of diabetes (30% vs. 20%) and previous stroke or transient ischemic attack (26% vs. 15%). During a median follow-up of 811 days, the rate of covert nonlacunar infarcts was significantly lower in the apixaban group than the aspirin group (5% vs. 18%). However, rates of symptomatic nonlacunar stroke did not differ significantly between the two groups (4% apixaban, 8% aspirin; P =0.30).

This study is useful for hypothesis generation, but it is not conclusive. The patients in the MRI substudy were imbalanced in key baseline characteristics, and the small overall number of outcome events makes the results tenuous. Right now, DOACs are not first-line treatment for patients with ESUS-type strokes.

Read more | >

Traditional biochemical methods of studying human gene mutations are often laborious and costly. Now bioengineers at the University of California San Diego have developed a new simple approach to rapidly check on human gene changes and also screen chemicals as potential drugs by turning everyday bacteria into living test tubes.

The researchers published their new study in the April 30 issue of Nature Biomedical Engineering.

Human cells carry thousands of genes, and tiny changes in these genes can cause serious diseases. Usually, scientists study these changes by testing proteins in a test tube or in human cells. But those methods can be slow, expensive and sometimes hard to do.

Read more | >

As global demand for electric vehicles and renewable energy storage surges, so does the need for affordable and sustainable battery technologies. A new study has introduced an innovative solution that could impact electrochemical energy storage technologies.

The research is published in the journal Advanced Functional Materials. The work was led by researchers from the Department of Materials Science and NanoEngineering at Rice University, along with collaborators from Baylor University and the Indian Institute of Science Education and Research Thiruvananthapuram.

Using an oil and gas industry’s byproduct, the team worked with uniquely shaped —tiny cones and discs—with a pure graphitic structure. These unusual forms produced via scalable pyrolysis of hydrocarbons could help address a long-standing challenge for anodes in battery research: how to store energy with elements like sodium and potassium, which are far cheaper and more widely available than lithium.

Read more | >

For the first time, a research team has successfully produced one of the most neutron-rich isotopes, hydrogen-6, in an electron scattering experiment.

The experiment at the spectrometer facility at the Mainz Microtron (MAMI) was a joint effort among the A1 Collaboration at the Institute of Nuclear Physics at Johannes Gutenberg University Mainz (JGU) and scientists from China and Japan. The team presents a new method for investigating light, neutron-rich nuclei and challenges our current understanding of multi-nucleon interactions.

“This measurement could only be carried out thanks to the unique combination of the excellent quality of the MAMI and the three high-resolution spectrometers of the A1 Collaboration,” emphasized Professor Josef Pochodzalla from the JGU Institute of Nuclear Physics. Researchers from Fudan University in Shanghai in China as well as from Tohoku University Sendai and the University of Tokyo in Japan were involved in the experiment.

Read more | >

Scientists have discovered that a medication already approved for treating multiple sclerosis and psoriasis shows remarkable promise in combating periodontitis, one of the leading causes of tooth loss worldwide.

Researchers from Wenzhou Medical University found that dimethyl fumarate (DMF) significantly reduced bone loss and inflammation in experimental models of gum disease by improving cellular “cleanup” mechanisms and shifting immune responses toward healing rather than destruction.

“Dimethyl fumarate’s ability to fine-tune macrophage polarization through mitophagy is a game-changer in periodontal therapy,” said Dr. Shengbin Huang, the study’s corresponding author. “By targeting the mitochondrial protein TUFM, we uncovered a molecular switch that controls the inflammatory response in gum tissue. These insights could redefine how we treat chronic inflammatory conditions beyond the oral cavity.”

Read more | >

Scientific article mentioned:
https://link.springer.com/article/10.1007/s10522-025-10240-z.

You can donate via our website:
https://www.rejuvenescimento.org/

This experiment is partially funded by DoNotAge.org and Heales Foundation, and it’s also funded by many smaller donations.

https://www.rejuvenescimento.org/newsletter-english.

Instagram:
https://www.instagram.com/rejuvenescimentoicr/

LinkedIn:

Continue reading “New article supports research on small EVs” | >