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Feb 24, 2019

Cannabis Therapeutics and the Future of Neurology

Posted by in categories: biotech/medical, neuroscience

Neurological therapeutics have been hampered by its inability to advance beyond symptomatic treatment of neurodegenerative disorders into the realm of actual palliation, arrest or reversal of the attendant pathological processes. While cannabis-based medicines have demonstrated safety, efficacy and consistency sufficient for regulatory approval in spasticity in multiple sclerosis (MS), and in Dravet and Lennox-Gastaut Syndromes (LGS), many therapeutic challenges remain. This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). Current basic science and clinical investigations support the safety and efficacy of such interventions in treatment of these currently intractable conditions, that in some cases share pathological processes, and the plausibility of interventions that harness endocannabinoid mechanisms, whether mediated via direct activity on CB1 and CB2 (tetrahydrocannabinol, THC, caryophyllene), peroxisome proliferator-activated receptor-gamma (PPARγ; THCA), 5-HT1A (CBD, CBDA) or even nutritional approaches utilizing prebiotics and probiotics. The inherent polypharmaceutical properties of cannabis botanicals offer distinct advantages over the current single-target pharmaceutical model and portend to revolutionize neurological treatment into a new reality of effective interventional and even preventative treatment.

Keywords: cannabis, pain, brain tumor, epilepsy, Alzheimer disease, Parkinson disease, traumatic brain injury, microbiome.

Cannabis burst across the Western medicine horizon after its introduction by William O’Shaughnessy in 1838 (O’Shaughnessy, 1838–1840; Russo, 2017b), who described remarkable successes in treating epilepsy, rheumatic pains, and even universally fatal tetanus with the “new” drug. Cannabis, or “Indian hemp,” was rapidly adopted by European physicians noting benefits on migraine by Clendinning in England (Clendinning, 1843; Russo, 2001) and neuropathic pain, including trigeminal neuralgia by Donovan in Ireland (Donovan, 1845; Russo, 2017b). These developments did not escape notice of the giants of neurology on both sides of the Atlantic, who similarly adopted its use in these indications: Silas Weir Mitchell, Seguin, Gowers and Osler (Mitchell, 1874; Seguin, 1877; Gowers, 1888; Osler and McCrae, 1915).

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Feb 24, 2019

New material could ‘drive wound healing’ using the body’s inbuilt healing system

Posted by in categories: biotech/medical, materials

Imperial researchers have developed a new bioinspired material that interacts with surrounding tissues to promote healing.

Materials are widely used to help heal wounds: Collagen sponges help treat burns and pressure sores, and scaffold-like implants are used to repair broken bones. However, the process of tissue repair changes over time, so scientists are looking to biomaterials that interact with tissues as healing takes place.

Continue reading “New material could ‘drive wound healing’ using the body’s inbuilt healing system” »

Feb 24, 2019

How Do You Preserve History On The Moon?

Posted by in category: space

As the 50th anniversary of the Apollo 11 lunar landing nears, some say the site of the first footprints on the moon should be protected. But historic preservation off our planet is unprecedented.

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Feb 24, 2019

Radical New Technologies will Make People “Super Human” and the Government More Efficient

Posted by in categories: computing, government, transhumanism

In my continuing work with the government of UAE / #Dubai, I have an article on #transhumanism that came out in a new portal launched with their recent World Government Summit 2019. Give it a read!


Everywhere around us a “super human” future is rapidly appearing. Sometimes called transhumanism, scientists, programmers, and engineers everywhere are working on radical technologies that not only become a part of our everyday reality, but also fit directly into our bodies.

Some examples are contact lenses that see in the dark. Others are endoskeletons attached to artificial limbs that can lift a half ton of weight. Still others are brain chip implants that read your thoughts and instantly communicate them with others. Sound like science fiction? Indeed, it does. Nevertheless, it’s coming very soon. In fact, much of the technology already exists. Some of it’s being sold commercially at your local superstore or being tested in laboratories right now around the world.

Continue reading “Radical New Technologies will Make People ‘Super Human’ and the Government More Efficient” »

Feb 24, 2019

Self-Driving Cars Might Kill Auto Insurance as We Know It

Posted by in categories: robotics/AI, transportation

Without humans to cause accidents, 90% of risk is removed. Insurers are scrambling to prepare.

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Feb 24, 2019

James Hughes’ Problems of Transhumanism: A Review (Part 3) – Article

Posted by in category: transhumanism

This is Part 3 of a 5-part series by Chogwu Abdul, founder of the Transhumanist Enlightenment Café (TEC), where he explores the thought-provoking intricacies of James Hughes’ “Problems of Transhumanism.”

In this Part, he explores “Liberal Democracy Versus Technocratic Absolutism.”

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Feb 24, 2019

My robotic team at CRC competition( −600 $ of budget)

Posted by in category: robotics/AI

128 votes and so far on Reddit.

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Feb 24, 2019

Thirty-million-page backup of humanity headed to moon aboard Israeli lander

Posted by in category: space

If the apocalypse hits, the Arch Mission Foundation wants to be sure the knowledge we’ve accrued sticks around.

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Feb 24, 2019

NASA greenlights SpaceX crew capsule test to ISS

Posted by in categories: robotics/AI, space travel

NASA on Friday gave SpaceX the green light to test a new crew capsule by first sending an unmanned craft with a life-sized mannequin to the International Space Station.

“We’re go for launch, we’re go for docking,” said William Gerstenmaier, the associate administrator with NASA Human Exploration and Operations.

A Falcon 9 rocket from the private US-based SpaceX is scheduled to lift off, weather permitting, on March 2 to take the Crew Dragon test capsule to the ISS.

Continue reading “NASA greenlights SpaceX crew capsule test to ISS” »

Feb 24, 2019

A quantum magnet with a topological twist

Posted by in categories: particle physics, quantum physics

Taking their name from an intricate Japanese basket pattern, kagome magnets are thought to have electronic properties that could be valuable for future quantum devices and applications. Theories predict that some electrons in these materials have exotic, so-called topological behaviors and others behave somewhat like graphene, another material prized for its potential for new types of electronics.

Now, an international team led by researchers at Princeton University has observed that some of the in these magnets behave collectively, like an almost infinitely massive electron that is strangely magnetic, rather than like individual particles. The study was published in the journal Nature Physics this week.

The team also showed that placing the kagome magnet in a causes the direction of magnetism to reverse. This “negative magnetism” is akin to having a compass that points south instead of north, or a refrigerator magnet that suddenly refuses to stick.

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