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The calls started pouring in soon after word spread that Dr. Valerie Taylor was testing fecal microbiota transplantation — transferring poop from one body to another — for bipolar disorder.

The mental health condition is different from depression. It comes with mania, the “up” swings that can make people feel superhuman. “But so many people with depression called wanting to take part in the study we felt we had an obligation to try,” said Taylor, chief of psychiatry at the University of Calgary.

Two years after spearheading the bipolar study, the first of its kind in the world, Taylor has now launched a second study testing fecal transplants in people with depression, as well as a third for depression in people who also have irritable bowel syndrome.

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Wormholes, passageways that connect one universe or time to another, are still only theoretical — but that doesn’t mean physicists aren’t looking for them. In a new study, researchers describe how to find wormholes in the folds of our galaxy.

These hypothetical passageways, created by folding a region of space like a piece of paper, are predicted by Einstein’s theory of general relativity. But they require extreme gravitational conditions, such as those around supermassive black holes.

In the new study, two researchers came up with a method to search for wormholes close to home, around the Milky Way’s central, supermassive black hole, called Sagittarius A*. If a wormhole were to exist around Sagittarius A*, the stars on one side of the passage would be influenced by the gravity of stars on the other side, the researchers said.

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Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.

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