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Blog – Page 8735

Holon-based cancer immunotherapy company Compugen disclosed encouraging preliminary results on Tuesday from its Phase 1 clinical trial for an antibody acting against a novel cancer drug target (PVRIG) in patients with advanced solid tumors.

The Nasdaq and Tel Aviv-listed company, a pioneer in predictive drug target discovery, has developed innovative computational discovery platforms to identify new drug targets and subsequently produce first-in-class therapeutics. The clinical trial of the anti-PVRIG antibody, called COM701, aimed to assess the safety of escalating doses of the therapy in patients with advanced solid tumors, but also demonstrated initial signals of anti-tumor activity in the heavily pre-treated patient population enrolled in the study.

“We are encouraged by the emerging safety profile and initial signals of anti-tumor activity of COM701,” said Compugen president and CEO Dr. Anat Cohen-Dayan.

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“…consider Robert Nozick’s thought-experiment in conjunction with Felipe De Brigard’s inverse experience machine argument: “If you like it, does it matter if it’s real?”

Does Nozick’s experience machine prove anything?

Perhaps consider Robert Nozick’s thought-experiment in conjunction with Felipe De Brigard’s inverse experience machine argument: “If you like it, does it matter if it’s real?”

Continue reading “David Pearce — Experience Machines and Hedonic Treadmills” | >

“Unplugged Performance thoroughly reworks the suspension with a custom race valved adjustable coilover suspension kit, along with billet adjustable front upper control arms, billet adjustable rear camber and toe arms and a beefier 3 way adjustable front/rear sway bar set with uprated bushings. The highly adjustable suspension and handling capabilities pair with massive 6 piston 15.5” uprated brakes and competition brake pads. Unplugged Performance 20” wheels shod with Michelin Cup 2 tires are then fitted. The wheels are custom machined out of 6061-T6 billet APP forgings, the same forgings used by Koenigsegg and Lamborghini, and every set is FEA optimized and specifically engineered to the specific build’s desired spec and use. Wheel weights range from 19.6–21.0lbs in 20” with tire sizings up to 305mm wide.”

While Tesla is working on a track-focused Model S, the Model 3 Performance is getting its own street-legal racing treatment from Unplugged Performance.

We previously reported on Unplugged Performance (UP), which is one of a few aftermarket accessories and performance upgrade companies focused solely on Tesla vehicles.

Continue reading “Tesla Model 3 Performance gets stunning street-legal racing treatment from Unplugged” | >

I think this is real but some say it isn’t.

A mysterious star whose repeated bouts of darkening might be due to “alien megastructures,” according to some researchers’ conjectures, may now have more than a dozen counterparts that display similarly mystifying behavior, a new study finds.

Further research into all of these stars might help solve the puzzle of their bewildering flickering, the study’s author said.

In 2015, scientists noticed unusual fluctuations in the light from a star named KIC 8462852. This otherwise-normal F-type star, which is slightly larger and hotter than Earth’s sun, sits about 1,480 light-years from Earth, in the constellation Cygnus.

Continue reading “‘Alien Megastructure’ Star May Not Be So Special After All” | >

Learn more about nuclear weapons and what you can do to stop them.
EN: http://www.notonukes.org
FR: http://www.sansarmesnucleaires.org
ES: http://www.nomasarmasnucleares.org
PT: http://www.fimdasarmasnucleares.org
DE: http://www.neinzuatomwaffen.org
AR: http://www.notonukes.org/ar
RU: http://www.notonukes.org/ru
CH: http://www.notonukes.org/zh

Spread the word and use the following Hashtags:
EN: #nuclearban FR: #nuclearban
ES: #nomasarmasnucleares
PT: #fimdasarmasnucleares

Sources:
https://sites.google.com/view/nuclearweapons/

As you may have noticed, we like to blow stuff up on this channel. So when the International Red Cross approached us to collaborate on a video about nuclear weapons, we were more than excited.

Continue reading “What if We Nuke a City?” | >

It’s been called an online Iron Curtain.

On Friday, a controversial law went into force that enables Russia to try to disconnect its internet from the rest of the world, worrying critics who fear the measure will promote online censorship.

The Kremlin says its “sovereign internet” law, which was signed by President Vladimir Putin in May, is a security measure to protect Russia in the event of an emergency or foreign threat like a cyberattack. The law will allow Moscow to tighten control over the country’s internet by routing web traffic through state-controlled infrastructure and creating a national system of domain names.

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While some high – end electric vehicles ( like the most expensive Teslas ) are starting to approach those kinds of ranges, it still takes around 50 minutes for a full charge using the most powerful superchargers available. That’s a long time to hang around if you’re doing a cross-country trip that requires multiple pit stops.

The result is range anxiety, where people worry about running out of juice and facing delays due to the long time it takes to recharge their car s. There are two ways to tackle the problem: building higher-capacity batteries or charging existing ones faster.

Bigger batteries are a tricky problem, because vehicles face a balancing act between weight an d capacity. After a certain point the extra weight of batteries cancels out the boost in power they provide. There’s plenty of work into batteries with better energy density—how much charge they can hold for a specific weight—but there aren’t any major breakthroughs on the horizon.

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A new study from the Johns Hopkins University School of Medicine shows that selectively removing senescent cells—cells that no longer divide—from brains with a form of Alzheimer’s disease can reduce brain damage and inflammation and slow the pace of cognitive decline. These findings, say researchers, add to evidence that senescent cells contribute to the damage caused by Alzheimer’s disease.

“Our results show that eliminating these cells may be a viable route to treat Alzheimer’s disease in humans,” says Mark Mattson, a professor of neuroscience at the School of Medicine and a senior investigator in the Laboratory of Neurosciences at the National Institute on Aging.

A report on the work was published April 1 in Nature Neuroscience.

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