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This year, Rockefeller scientists plumbed the depths of wound repair and tackled how songbirds solve problems; they used microchips to grow mini-lungs and proposed an environmental trigger for multiple sclerosis. Efforts to combat COVID, Hepatitis B, and other infections bore fruit, and countless papers shed light on basic research, answering questions that have long baffled biologists. Here are some of the intriguing discoveries that came out of Rockefeller in 2023.

Old sperm, new mutations

As the male reproductive system ages, it becomes more and more susceptible to mutations. New research from the laboratory of Li Zhao explored this phenomenon in fruit flies, by focusing on how mutations arise during the formation of sperm. The team found that, while mutations are common in the testes of both young and old flies, the repair mechanisms that remove those mutations and maintain genomic integrity during spermatogenesis become less efficient in older individuals, leading to the accumulation and persistence of more mutations in older flies.

Computing has already accelerated scientific discovery. Now scientists say a combination of advanced AI with next-generation cloud computing is turbocharging the pace of discovery to speeds unimaginable just a few years ago.

Microsoft and the Pacific Northwest National Laboratory (PNNL) in Richland, Washington, are collaborating to demonstrate how this acceleration can benefit chemistry and materials science – two scientific fields pivotal to finding energy solutions that the world needs.

Scientists at PNNL are testing a new battery material that was found in a matter of weeks, not years, as part of the collaboration with Microsoft to use to advanced AI and high-performance computing (HPC), a type of cloud-based computing that combines large numbers of computers to solve complex scientific and mathematical tasks.

Microsoft presents LLMs in the Imaginarium.

Tool Learning through Simulated Trial and Error https://huggingface.co/papers/2403.

Tools are essential for large language models (LLMs) to acquire up-to-date information and take consequential actions in external environments.

Continue reading “LLMs in the Imaginarium: Tool Learning through Simulated Trial and Error” »

Chatbot Arena.

An open platform for evaluating llms by human preference.

Large Language Models (LLMs) have unlocked new capabilities and applications; however, evaluating the alignment with human preferences still poses significant challenges.

Continue reading “Chatbot Arena: An Open Platform for Evaluating LLMs by Human Preference” »

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Freya India is a writer and journalist focussed on female mental health and modern culture. Gen Z girls are not doing ok. No matter how badly you think men have it right now (and they do), girls are doing no better.

The Rebellionaire Road Rally has made its way down to Austin, TX. This time we’re joined by Farzad (@farzyness) to test out Tesla FSD v12 on the streets of the greater Austin area. This is part 2 of the journey with Farzad joining in the car adding helpful commentary.

#Tesla #rebellionaire.

Continue reading “Tesla FSD v12 drives like a teenager!” »

Thrombolytic therapy administered longer after the onset of ischemic stroke than current recommendations did not demonstrate improved clinical outcomes as compared to placebo, according to a recent trial published in the New England Journal of Medicine.

Minjee Kim, MD, associate professor in the Ken and Ruth Davee Department of Neurology’s Division of Neurocritical Care, was a co-author of the study.

Ischemic stroke occurs when a blood vessel supplying blood to the brain is blocked or reduced, and accounts for nearly 90% of all strokes, according to statistics from the American Stroke Association.

Blood in animals provides oxygen and nutrients to the organs and cells of the body. However, if blood supply is interrupted, these cells soon perish and organs are damaged.