The University of Cambridge’s Dr. William Bains provides a thorough overview of extracellular cross-links in this lecture. He explains that advanced glycation end-products (AGEs) can irreversibly link proteins together, and cross-linking AGEs appear to play an important role in aging. They are particularly problematic in the cardiovascular system, where cross-links cause our arteries to stiffen with age, raising blood pressure and making a patient more likely to suffer from a heart attack or stroke. Cross-links are also implicated in complications from diabetes. Dr. Bains explains the structure and nature of cross-links, where they accumulate in the body, and even what their surprising role is in cooking. He ends by discussing a major AGE-breaking drug that has been tested on humans and touches on potential future therapies.
Visit www.sens.org/videos to view the rest of our course lecture videos.
Diagnosed with terminal lung cancer, Joe was told he had about 3 months to live. A veterinarian friend of his in western Oklahoma called him and told him about a cancer research experiment he had learned about in which a dog-deworming medicine had cured cancer in the experimental mice… and when the researcher developed cancer, she used the same medicine on herself and her glioblastoma was gone in about 12 weeks.
With nothing to lose and everything to gain, Joe ordered the veterinary product, Fenbendazole, and began taking it. He added a few other things to his regimen such as curcumin and Vitamin E, now known as the “Joe Tippens Protocol”. Three and a half months later, he went in for a scan and he was totally clear!
Joe’s Website: https://www.mycancerstory.rocks/
Joe’s Facebook (group is limited): https://www.facebook.com/groups/mycancerstoryrocks/
See more cancer Survivor Stories at: https://templetonwellness.com/survivor-stories/
Fresh evidence of an unknown particle that could carry a fifth force of nature gives the NA64 collaboration at CERN a new incentive to continue searches.
In 2015, a team of scientists spotted an unexpected glitch, or “anomaly,” in a nuclear transition that could be explained by the production of an unknown particle. About a year later, theorists suggested that the new particle could be evidence of a new fundamental force of nature, in addition to electromagnetism, gravity and the strong and weak forces. The findings caught worldwide attention and prompted, among other studies, a direct search for the particle by the NA64 collaboration at CERN.
A new paper (pdf) from the same team, led by Attila Krasznahorkay at the Atomki institute in Hungary, now reports another anomaly, in a similar nuclear transition, that could also be explained by the same hypothetical particle.
The term “Isotonic” originates from the Greek root words “iso” and “tonos.” The root “iso” isn’t just a file format, it actually means equal. “Tonos,” on the other hand, means to stretch. The word Isotonic can mean a multitude of things stretching from material and physical sciences to liberal arts.
Equal Stretch Regression (Isotonic Regression) is a really cool model for statistical inference. My obsession with isotonic regression has long been expanding, because the model is just so interesting, and cool.
Last week we covered how the Tesla Cybertruck’s aerodynamics might be better than its boxy shape suggests, and today Tesla CEO Elon Musk responded to the numbers and suggested that the Cybertruck could get a Cd (drag coefficient) as low as .3 – quite impressive for a pickup truck.
A popular WiFi chip, ESP32, contains a security flaw that enables hackers to implant malware that can never be removed. The attack works by implanting code into eFuses, a chip feature that can only be configured once.
H.I.V. Is Coming to Rural America
Posted in health
San Francisco and Chicago have also seen their rates of new H.I.V. infections falling.
But while robust municipal health campaigns are creating downward H.I.V. trends in some of America’s largest cities, in much of rural America, an opposite trend is emerging. There have of course always been cases of H.I.V. in sparsely populated parts of the country, but in these places far from cities, the conditions that lead to H.I.V. transmission are now intensifying — and rural America is not ready for the coming crisis.
Indeed, in Appalachian West Virginia, the crisis has already arrived. A cluster of 80 new H.I.V. infections has been diagnosed since early last year in Cabell County.
3D printed corneas
Posted in 3D printing, innovation
Millions of people need new corneas. In a major breakthrough, researchers can now 3D print them.
What if you could cheat death and live forever? To people in the radical life extension movement, immortality is a real possibility. Leah Green spends a long weekend at RAADfest, a meeting of scientists, activists and ordinary people who want to extend the human lifespan. So is reversing your age a real possibility? And what’s behind this wish to live forever?
This is the first episode in our Death Land series, with a new episode every Thursday at 12pm. Subscribe here so you don’t miss the next installment ► http://is.gd/subscribeguardian
Support the Guardian ► https://support.theguardian.com/contribute
Today in Focus podcast ► https://www.theguardian.com/news/series/todayinfocus
Sign up for the Guardian documentaries newsletter ► https://www.theguardian.com/info/2016/sep/02/sign-up-for-the…ies-update