Is ageing a disease? One that can be ‘cured’? BBC’s Gabriela Torres meets the self-experimenters and scientists who are trying to dramatically extend our lives.
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A molecular switch has been identified by scientists at the University of California that controls the immune machinery which is responsible for chronic inflammation within the body; findings published in the journal Cell Metabolism may lead to new ways to halt and/or reverse age related conditions such as cancer, diabetes, Alzheimer’s and Parkinson’s disease.
“My lab is very interested in understanding the reversibility of aging,” said senior author Danica Chen, associate professor of metabolic biology, nutritional sciences and toxicology at UC Berkeley. “In the past, we showed that aged stem cells can be rejuvenated. Now, we are asking: to what extent can aging be reversed? And we are doing that by looking at physiological conditions, like inflammation and insulin resistance, that have been associated with aging-related degeneration and diseases.”
A bulky collection of NLRP3 inflammasome immune proteins which are responsible for sensing potential threats to the body and launching an inflammatory response were shown to be essentially switched off by removing some molecular matter in a deacetylation process. Overactivation of NLRP3 inflammasomes is linked to a range of chronic conditions such as cancer, dementia, diabetes, and multiple sclerosis; this study suggests that drugs targeted towards deacetylation these NLRP3 inflammasomes may help to prevent and/or treat many age related conditions and even possibly age related degeneration itself in general.
Autonomous delivery robots join the fight against the #coronavirus epidemic in Wuhan, China.
Every crisis is an opportunity. With everyone staying home, this is the perfect opportunity for e-commerce, e-learning, online jobs, and big tech to expand. This is the beginning of a huge tech revolution. 2020 will be the techade (technology decade).
The virus is hitting China’s economy hard, but this is likely only temporary. China’s immune system is fighting back — building hospitals in record time, completely locking down a city and most importantly the entire nation uniting as one voice of support and solidarity.
Mario Cavolo called out the global response to the Coronavirus in his post “Something’s not right here folks” which originally went viral on LinkedIn and then subsequently all over Chinese social media. He compares the media response to Coronavirus with the H1N1 outbreak in the US, saying, “it’s not a conspiracy, it’s just a tragedy,” and “this vicious, political, xenophobic racist attacks and smearing of all things China needs to stop.”
What doesn’t break you only makes you stronger, and the Chinese people are resilient and will find ways to rise out of this crisis, likely coming back even stronger than before. How long that will take no-one yet knows, but the Chinese spirit is not even close to being broken, and we’ve seen how Chinese ingenuity in a time of crisis has led to entirely new operating models.
Grocery and ecommerce shopping delivered… by drone? As shoppers get more delivered, companies look to cut last mile costs. Business Insider looks at how Amazon, UPS and Domino’s are experimenting with drone delivery.
New Zealand Police has recruited an unusual new officer to the force: an AI cop called Ella.
Ella is a life-like virtual assistant that uses real-time animation to emulate face-to-face interaction in an empathetic way.
Granule cells improve the storage capacity of the brain using the same trick that is used to compress digital audio files into an MP3.
Circa 2019
Nature breaks everything down—eventually. It’s time to accelerate the process, by engineering enzymes or microbes to chop plastic polymers into bits.
Like buoys bobbing on the ocean, many receptors float on the surface of a cell’s membrane with a part sticking above the water and another underwater, inside the cell’s cytoplasm. But for cells to function, these receptors must be docked at specific regions of the cell. Most research has focused on the ‘underwater’ portions. That’s where the cell’s molecular machines swarm and interact with a receptor’s underwater tails, with those interactions then fueling signals that dive deep into the nucleus, changing the cell’s course.
New work by a team of Thomas Jefferson University researchers reveals new activity above the surface, in brain-cell receptors that govern learning and chronic pain. In the study, the authors show that the ‘above water’ portion of proteins can help dock the proteins at synapses, where neurons mediate flow of information throughout the brain. This discovery opens the possibility of using this docking site as a target to develop treatments for chronic pain and other diseases more effectively. The study was published January 29th in Nature Communications.
“The extracellular spaces — the parts ‘above the water’ — have been largely overlooked,” says senior author Matthew Dalva, PhD, professor and vice chair of the Department of Neuroscience and director of the Jefferson Synaptic Biology Center in the Vickie & Jack Institute for Neuroscience — Jefferson Health. Dr. Dalva and his team looked at the NMDAR receptor on brain cells and pinpointed the spot where this receptor interacts with a neighbor to initiate signaling. “When trying to develop new therapy, finding the bullseye is half the problem,” says Dr. Dalva.
