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Circa 2017
We have reported a new phenomenon in acute wound healing following the use of intracellular ATP delivery—extremely rapid tissue regeneration, which starts less than 24 h after surgery, and is accompanied by massive macrophage trafficking, in situ proliferation, and direct collagen production. This unusual process bypasses the formation of the traditional provisional extracellular matrix and significantly shortens the wound healing process. Although macrophages/monocytes are known to play a critical role in the initiation and progression of wound healing, their in situ proliferation and direct collagen production in wound healing have never been reported previously. We have explored these two very specific pathways during wound healing, while excluding confounding factors in the in vivo environment by analyzing wound samples and performing in vitro studies. The use of immunohistochemical studies enabled the detection of in situ macrophage proliferation in ATP-vesicle treated wounds. Primary human macrophages and Raw 264.7 cells were used for an in vitro study involving treatment with ATP vesicles, free Mg-ATP alone, lipid vesicles alone, Regranex, or culture medium. Collagen type 1α 1, MCP-1, IL-6, and IL-10 levels were determined by ELISA of the culture supernatant. The intracellular collagen type 1α1 localization was determined with immunocytochemistry. ATP-vesicle treated wounds showed high immunoreactivity towards BrdU and PCNA antigens, indicating in situ proliferation. Most of the cultured macrophages treated with ATP-vesicles maintained their classic phenotype and expressed high levels of collagen type 1α1 for a longer duration than was observed with cells treated with Regranex. These studies provide the first clear evidence of in situ macrophage proliferation and direct collagen production during wound healing. These findings provide part of the explanation for the extremely rapid tissue regeneration, and this treatment may hold promise for acute and chronic wound care.
Wound healing is a complex and dynamic process involving the replacement of devitalized and missing structures. The traditional view of wound healing is that it involves hemostasis, inflammation, proliferation, and remodeling, and these steps result in a lag of 3–6 d before reepithelialization starts [1,2]. We have discovered that the intracellular delivery of adenosine triphosphate using ATP-vesicles as an acute wound treatment enhances wound healing [3,4]. The most unprecedented finding was that new tissue started to generate within 24 h, and it continued to grow to eliminate the wound cavity quickly [4–6]. This growth was attained by early and massive monocyte/macrophage trafficking, proliferation, and fast collagen production for direct formation of extracellular matrix (ECM).
GONE ARE the days when conspiracy-mongers had to find shards of evidence and contort it to convince people. Now, just their malevolence is needed. If a concocted scenario can’t be proved, then perhaps it can’t be disproved either. That is toxic for a stable society and politics. So how did we get here, and how do we get out?
Nancy L. Rosenblum of Harvard University and Russell Muirhead of Dartmouth College are the authors of “A Lot of People Are Saying: The New Conspiracism and the Assault on Democracy” (Princeton, 2019). Though conspiracy theories have always existed, they note that today something is different and dangerous: “Conspiracy without the theory.”
We need to have higher ethics for robotic beings because if the superintelligence in digital form becomes reality we will need to have better ethics around robot rights. We could have literally a terminator situation but we could make a the vision possibly we do not need to have them be slaves to use but rightful citizens.
Each notice cited the same section of these guidelines, which states: “Content that displays the deliberate infliction of animal suffering or the forcing of animals to fight is not allowed on YouTube.”
It goes on to state: “Examples include, but are not limited to, dog fighting and cock fighting.”
Continue reading “YouTube is deleting videos of robots fighting because of ‘animal cruelty’” »
Cambridge Quantum Computing has a demo of its quantum key security generation at Ironbridgeapi.com.
A provocative new study is suggesting a blood test tracking 14 different biomarkers can predict a person’s risk of dying within the next 10 years better than any conventional models. The research is still a long way off being broadly deployed in clinical environments and the test may be of most use in human drug trials as a surrogate endpoint for mortality.
© 2019 EPFL / Alain Herzog. OpticSELINE electrode array for intraneural stimulation of the optic nerve, developed in the Translational Neural Engineering Lab, and used in preliminary studies.
Vast interstellar events where clouds of charged matter hurtle into each other and spew out high-energy particles have now been reproduced in the lab with high fidelity. The work, by MIT researchers and an international team of colleagues, should help resolve longstanding disputes over exactly what takes place in these gigantic shocks.
Many of the largest-scale events, such as the expanding bubble of matter hurtling outward from a supernova, involve a phenomenon called collisionless shock. In these interactions, the clouds of gas or plasma are so rarefied that most of the particles involved actually miss each other, but they nevertheless interact electromagnetically or in other ways to produces visible shock waves and filaments. These high-energy events have so far been difficult to reproduce under laboratory conditions that mirror those in an astrophysical setting, leading to disagreements among physicists as to the mechanisms at work in these astrophysical phenomena.
Now, the researchers have succeeded in reproducing critical conditions of these collisionless shocks in the laboratory, allowing for detailed study of the processes taking place within these giant cosmic smashups. The new findings are described in the journal Physical Review Letters, in a paper by MIT Plasma Science and Fusion Center Senior Research Scientist Chikang Li, five others at MIT, and 14 others around the world.
WASHINGTON — Several hundred million ash trees around the nation have fallen victim to a beetle known as the emerald ash borer. Thousands of doomed trees once stood tall in the D.C. area, according to bug guy Mike Raupp, an entomologist at the University of Maryland.
“This is a devastating pest,” said Raupp.
Local governments are fighting back against what Raupp says is a tsunami of the beetles, which chew their way into the tree and feed on what’s underneath the bark.
Researchers at the University of Sfax, in Tunisia, have recently developed a new method to recognize handwritten characters and symbols in online scripts. Their technique, presented in a paper pre-published on arXiv, has already achieved remarkable performance on texts written in both the Latin and Arabic alphabet.
In recent years, researchers have created neural network-based architectures that can tackle a variety of tasks, including image classification, face recognition, natural language processing (NLP), and many more. Handwriting recognition systems are computer tools that are specifically designed to recognize characters and other hand-written symbols in a similar way to humans.
In their early years of life, in fact, human beings innately develop the ability to understand different types of handwriting by identifying specific characters both individually and when grouped together. Over the past decade or so, many studies have tried to replicate this ability in computer systems, as this would ultimately enable more advanced and automatic analyses of handwritten texts.
