Lifeboat Foundation: Safeguarding Humanity
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When DARPA launched its Pandemic Preparedness Platform (P3) program two years ago, the pandemic was theoretical. It seemed like a prudent idea to develop a quick response to emerging infectious diseases. Researchers working under the program sought ways to confer instant (but short-term) protection from a dangerous virus or bacteria.

Today, as the novel coronavirus causes a skyrocketing number of COVID-19 cases around the world, the researchers are racing to apply their experimental techniques to a true pandemic playing out in real time. “Right now, they have one shot on goal,” says DARPA program manager Amy Jenkins. “We’re really hoping it works.”

The P3 program’s plan was to start with a new pathogen and to “develop technology to deliver medical countermeasures in under 60 days—which was crazy, unheard of,” says Jenkins. The teams have proven they can meet this ambitious timeline in previous trials using the influenza and Zika viruses. Now they’re being asked to pull off the same feat with the new coronavirus, which more formally goes by the name SARS-CoV-2 and causes the illness known as COVID-19.

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Getting plenty of deep, restful sleep is essential for our physical and mental health. Now comes word of yet another way that sleep is good for us: it triggers rhythmic waves of blood and cerebrospinal fluid (CSF) that appear to function much like a washing machine’s rinse cycle, which may help to clear the brain of toxic waste on a regular basis.

The video above uses functional magnetic resonance imaging (fMRI) to take you inside a person’s brain to see this newly discovered rinse cycle in action. First, you see a wave of blood flow (red, yellow) that’s closely tied to an underlying slow-wave of electrical activity (not visible). As the blood recedes, CSF (blue) increases and then drops back again. Then, the cycle—lasting about 20 seconds—starts over again.

The findings, published recently in the journal Science, are the first to suggest that the brain’s well-known ebb and flow of blood and electrical activity during sleep may also trigger cleansing waves of blood and CSF. While the experiments were conducted in healthy adults, further study of this phenomenon may help explain why poor sleep or loss of sleep has previously been associated with the spread of toxic proteins and worsening memory loss in people with Alzheimer’s disease.

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“It’s hard to find a body part they can’t regenerate: the limbs, the tail, the spinal cord, the eye, and in some species, the lens, even half of their brain has been shown to regenerate,” Kentucky researcher Randal Voss said in the release.

“Just a few years ago, no one thought it possible to assemble a 30+GB genome,” said Kentucky biologist Jeramiah Smith. “We have now shown it is possible using a cost effective and accessible method, which opens up the possibility of routinely sequencing other animals with large genomes.”

With that capability, the team hopes to begin probing the full DNA sequence for insights into the axolotl’s regenerative abilities.

“Now that we have access to genomic information, we can really start to probe axolotl gene functions and learn how they are able to regenerate body parts,” said Voss. “Hopefully someday we can translate this information to human therapy, with potential applications for spinal cord injury, stroke, joint repair… the sky’s the limit, really.”

Continue reading “Scientists: Salamander DNA Could Regenerate Human Body Parts” | >

“Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference…” “…Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections.”

Vaccine. 2020 Jan 10;38:350–354. doi: 10.1016/j.vaccine.2019.10.005. Epub 2019 Oct 10.

PURPOSE: Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. Test-negative study designs are often utilized to calculate influenza vaccine effectiveness. The virus interference phenomenon goes against the basic assumption of the test-negative vaccine effectiveness study that vaccination does not change the risk of infection with other respiratory illness, thus potentially biasing vaccine effectiveness results in the positive direction. This study aimed to investigate virus interference by comparing respiratory virus status among Department of Defense personnel based on their influenza vaccination status. Furthermore, individual respiratory viruses and their association with influenza vaccination were examined.

RESULTS: We compared vaccination status of 2880 people with non-influenza respiratory viruses to 3240 people with pan-negative results. Comparing vaccinated to non-vaccinated patients, the adjusted odds ratio for non-flu viruses was 0.97 (95% confidence interval (CI): 0.86, 1.09; p = 0.60). Additionally, the vaccination status of 3349 cases of influenza were compared to three different control groups: all controls (N = 6120), non-influenza positive controls (N = 2880), and pan-negative controls (N = 3240). The adjusted ORs for the comparisons among the three control groups did not vary much (range: 0.46−0.51).

Continue reading “Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017–2018 influenza season. — PubMed — NCBI” | >

The Curiosity rover analyzes compounds by breaking them down into fragments. The upcoming European Space Agency’s Rosalind Franklin rover, however, could fill in the gaps with its Mars Organic Molecule Analyzer (MOMA), which doesn’t use the same destructive technique as Curiosity.

What has Schulze-Makuch most excited is the possibility of finding differing ratios of heavy and light isotopes in compounds, the result of organisms breaking down elements and “a telltale signal for life,” according to the researcher.

“As Carl Sagan said ‘extraordinary claims require extraordinary evidence,’” Schulze-Makuch said. “I think the proof will really require that we actually send people there, and an astronaut looks through a microscope and sees a moving microbe.”

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Florida State University physicists believe they have an answer to unusual incidents of rare decay of a subatomic particle called a Kaon that were reported last year by scientists in the KOTO experiment at the Japan Proton Accelerator Research Complex.

FSU Associate Professor of Physics Takemichi Okui and Assistant Professor of Physics Kohsaku Tobioka published a new paper in the journal Physical Review Letters that proposes that this decay is actually a new, short-lived particle that has avoided detection in similar experiments.

“This is such a rare disintegration,” Okui said. “It’s so rare, that they should not have seen any. But if this is correct, how do we explain it? We think this is one possibility.”

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The largest private automaker in China is getting into the satellite business. Chinese automotive giant Geely has broadened its reach to include everything from trucking, to high-speed trains, to passenger drones, to Volvo over the last decade or so. But its newest effort could tie those things all together, as Geely just announced it’s going to build its own satellite network to enable what it calls a “smart three-dimensional mobility ecosystem.”

Geely announced late Monday that it will erect a satellite production facility and testing center in the port city of Taizhou in the Zhejiang province that the Chinese giant calls home. The facility will be capable of building a “variety of different satellite models,” some of which may be for non-Geely entities.

Geely says it will start launching the satellite network as soon as the end of this year, but did not say how big it will be. Reuters reports that the company is pumping around $326 million into the project, and will eventually make 500 satellites a year.

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