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Circa 2002 4 lines of code to solve everything.


… But first it cracked him. The inside story of how Stephen went from boy genius to recluse to science renegade.

Word had been out that Stephen, the onetime enfant terrible of the science world, was working on a book that would Say It All, a paradigm-busting tome that would not only be the definitive account on complexity theory but also the opening gambit in a new way to view the universe. But no one had read it.

Though physically unimposing with a soft, round face and a droll English accent polished at Eton and Oxford, had already established himself as a larger-than-life figure in the gossipy world of science. A series of much-discussed reinventions made him sort of the Bob Dylan of physics. He’d been a child genius, and at 21 had been the youngest member of the storied first class of MacArthur genius awards. After laying the groundwork for a brilliant career in particle physics, he’d suddenly switched to the untraditional pursuit of studying complex systems, and, to the establishment’s dismay, dared to pioneer the use of computers as a primary research tool. Then he seemed to turn his back on that field. He started a software company to sell Mathematica, a computer language he’d written that did for higher math what the spreadsheet did for business. It made him a rich man. Now he had supposedly returned to science to write a book that would make the biggest splash of all.

In a study of epilepsy patients, researchers at the National Institutes of Health monitored the electrical activity of thousands of individual brain cells, called neurons, as patients took memory tests. They found that the firing patterns of the cells that occurred when patients learned a word pair were replayed fractions of a second before they successfully remembered the pair. The study was part of an NIH Clinical Center trial for patients with drug-resistant epilepsy whose seizures cannot be controlled with drugs.

“Memory plays a crucial role in our lives. Just as are recorded as grooves on a record, it appears that our brains store memories in that can be replayed over and over again,” said Kareem Zaghloul, M.D., Ph.D., a neurosurgeon-researcher at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and senior author of the study published in Science.

Dr. Zaghloul’s team has been recording electrical currents of drug-resistant epilepsy patients temporarily living with surgically implanted electrodes designed to monitor in the hopes of identifying the source of a patient’s seizures. This period also provides an opportunity to study neural activity during memory. In this study, his team examined the activity used to store memories of our past experiences, which scientists call episodic memories.

An international team of scientists led by researchers at Karolinska Institutet in Sweden has launched a comprehensive overview of all proteins expressed in the brain, published today in the journal Science. The open-access database offers medical researchers an unprecedented resource to deepen their understanding of neurobiology and develop new, more effective therapies and diagnostics targeting psychiatric and neurological diseases.

The is the most complex organ, both in structure and function. The new Brain Atlas resource is based on the analysis of nearly 1,900 brain samples covering 27 , combining data from the human brain with corresponding information from the brains of the pig and mouse. It is the latest database released by the Human Protein Atlas (HPA) program which is based at the Science for Life Laboratory (SciLifeLab) in Sweden, a joint research centre aligned with KTH Royal Institute of Technology, Karolinska Institutet, Stockholm University and Uppsala University. The project is a collaboration with the BGI research centre in Shenzhen and Qingdao in China and Aarhus University in Denmark.

“As expected, the blueprint for the brain is shared among mammals, but the new map also reveals interesting differences between human, pig and mouse brains,” says Mathias Uhlén, Professor at the Department of Protein Science at KTH Royal Institute of Technology, Visiting professor at the Department of Neuroscience at Karolinska Institutet and Director of the Human Protein Atlas effort.

A new joint study by Tel Aviv University (TAU) and Weizmann Institute of Science researchers has yielded an innovative method for bolstering memory processes in the brain during sleep.

The method relies on a memory-evoking scent administered to one nostril. It helps researchers understand how sleep aids memory, and in the future could possibly help to restore memory capabilities following brain injuries, or help treat people with post– (PTSD) for whom memory often serves as a trigger.

The new study was led by Ella Bar, a Ph.D. student at TAU and the Weizmann Institute of Science. Other principal investigators include Prof. Yuval Nir of TAU’s Sackler Faculty of Medicine and Sagol School of Neuroscience, as well as Profs. Yadin Dudai, Noam Sobel and Rony Paz, all of Weizmann’s Department of Neurobiology. It was published in Current Biology on March 5.

Powerful antibiotics and widespread sanitation practices have expanded lifespans across the industrialized world. But they have also come at a cost. Our microbiomes, or the trillions of microbes collectively working in our bodies to help regulate our immune system and food digestion, have lost much of its health-promoting bacteria because of our modern lifestyles and sanitation practices.

Scientists across the world are now looking to the planet’s few remaining pre-industrialized societies to see what industrialized guts have lost–and in doing so, could fundamentally change the way scientists think about germs. Thomas Morton heads to the Central African Republic to see this emerging field of microbiome science.

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The researchers are hoping the extremely light material could be used to construct lightweight exoskeletons and shape-shifting “Terminator 2”-style robots, New Scientist reports.

Glass Beads

The researchers created a mixture of the soft metals gallium and indium, which had a melting point of just 15.7 Celsius (60.3 Fahrenheit). To make it float, the team gently stirred microscopic beads of glass, filled with air, into the liquid.