Lifeboat Foundation

Michigan State University and Stanford University scientists have invented a nanoparticle that eats away—from the inside out—portions of plaques that cause heart attacks.

Bryan Smith, associate professor of biomedical engineering at MSU, and a team of scientists created a “Trojan Horse” nanoparticle that can be directed to eat debris, reducing and stabilizing plaque. The discovery could be a potential treatment for atherosclerosis, a leading cause of death in the United States.

The results, published in the current issue of Nature Nanotechnology, showcases the nanoparticle that homes in on atherosclerotic plaque due to its high selectivity to a particular immune cell type—monocytes and macrophages. Once inside the macrophages in those plaques, it delivers a drug agent that stimulates the cell to engulf and eat cellular debris. Basically, it removes the diseased/dead cells in the plaque core. By reinvigorating the macrophages, plaque size is reduced and stabilized.

Recently, a team of researchers, including Professor Judy Campisi, has published an atlas charting the inflammatory senescence-associated secretory phenotype (SASP) [1].

The nature of the SASP

As we grow older, increasing numbers of our cells enter a state known as senescence. Senescent cells no longer divide to support and help maintain the tissues that they are a part of and instead secrete a range of harmful inflammatory signals: the SASP.

If your PC is running on any modern #Intel CPU built before Oct 2018, it’s likely vulnerable to a new hardware issue, dubbed CacheOut (CVE-2020–0549), that could let attackers leak sensitive data from OS kernel, VMs and even from SGX enclave. :-o.

Researchers demonstrated a new speculative execution vulnerability, dubbed ‘CacheOut’ assigned CVE-2020–0549, in Intel processors that could allow attackers to leak targeted sensitive data from OS kernel, co-resident virtual machines, and even stored within Intel’s secured SGX enclave.

The Air Force’s top general says one of the designers of the ride-sharing app Uber is helping the branch build a new data-sharing network that the Air Force hopes will help service branches work together to detect and destroy targets.

The network, which the Air Force is calling the advanced battle management system (ABMS), would function a bit like the artificial intelligence construct Cortana from Halo, who identifies enemy ships and the nearest assets to destroy them at machine speed, so all the fleshy humans need to do is give a nod of approval before resuming their pipe-smoking.

We are delighted to announce that Dr. Brian Kennedy, a Distinguished Professor in the Department of Biochemistry and Physiology at the National University of Singapore (NUS) will be joining the LEAF scientific advisory board.

Professor Kennedy is an important figure in the research community, as he is internationally recognized for his research and efforts to translate those findings into therapies that could potentially slow, delay, or even prevent age-related diseases. He previously served as the President of the Buck Institute, where he still remains as a Professor.

At the NUS, he is developing therapeutic interventions that directly target human aging along with biomarkers that can validate if a therapy has worked or not. Professor Kennedy and his team have been exploring the epigenetic clock, a biomarker that measures methylation of the human genome to determine biological age. They are also investigating inflammatory biomarkers of aging using metabolomics, the study of chemical processes involving metabolites, the intermediates and products of metabolism.

The world’s first completely robotic heart may end the need for transplants from dead humans in as few as 10 years, the hybrid heart made of soft artificial muscles and sensors is hoped to eventually end the need for human transplants.

The hybrid robotic heart is under development and could clear NHS heart transplant waiting lists and save many lives. It is the first hybrid heart made from soft artificial muscles and sensors which are coated in human tissues that are grown in a laboratory.

There are plans partnered with the British Heart Foundation to transplant it into the first person in 2028; the hope is that this hybrid robotic heart will save thousands of lives who would normally have died while waiting for a human organ donor on global waiting lists.

Link to study paper: https://link.springer.com/…/10.1007%2Fs11357-019–00113-y.pdf

A team of researchers have built what they claim to be the first living robots. The “xenobots,” they say, can move, pick up objects, and even heal themselves after being cut.

The team is hoping the biological machines could one day be used to clean up microplastics in the ocean or even deliver drugs inside the human body, The Guardian reports.

Continue reading “Scientists Build ‘First Living Robots’ From Frog Stem Cells” »

A research group at TU Wien has developed a terahertz radiation source that is both efficient and creates a broad spectrum, generating different wavelengths from the entire terahertz range. Both aspects are said to have broken previously held records.

#lasers #photonics